Expression of GRP-78 and RRBP1 in primary liver cancer and their association with early postoperative recurrence
Objective:To explore the expression of GRP-78,RRBP1 in primary liver cancer (PLC)tissue and its association with early postoperative recurrence.Methods:A total of 80 PLC patients diagnosed and surgically resected in our hospital from August 2018 to August 2021 were enrolled.Intraoperative tissues and PLC tissues were obtained.The expression of GRP-78,RRBP1 protein was detected by western blot.Patients were followed up for 2 years after discharge,and were divided into relapse group and non-recurrence group.Baseline data and GRP-78,RRBP1 levels were compared between the two groups.logistic regression was used to analyze the factors affecting the early recurrence of PLC after operation.ROC curve was used to analyze the value of GRP-78 and RRBP1 expression levels in the assessment of early postoperative recurrence of PLC.Results:The expressions of GRP-78 and RRBP1 in PLC tissues were significantly increased compared with those in adjacent tissues (P<0.05 ).There were significant differences in alcohol abuse history,number of tumors,degree of tissue differentiation,TNMstage,PTL and AFP in relapse group compared with non-relapse group (P<0.05).The levels of GRP-78 and RRBP1 in PLC tissues of patients with recurrence were significantly increased compared with those of non-recurrence group (P<0.05 ).History of alcoholism,number of tumors,degree of tissue differentiation,TNM stage,abnormal level of PTL,AFP,GRP-78 and RRBP1 were the risk factors affecting the prognosis of AHF (P<0.05 ).The AUC,sensitivity and specificity of GRP-78 and RRBP1 combined to predict early postoperative recurrence in PLC patients were 0.913,91.18％ and 89.36％,respectively,which were higher than the single prediction efficacy of the above indexes (P<0.05 ).Conclusion:The high expression of GRP-78 and RRBP1 in PLC tissues is closely related to the early postoperative recurrence of PLC patients,and the combined detection of GRP-78 and RRBP1 has higher predictive value for the early postoperative recurrence of PLC patients.
万方数据
维普
