Medication Rules of Traditional Chinese Medicine in Treating Acute Cerebral Infarction Based on Data Mining
Objective:Based on the data mining technology,to study the medication rules of traditional Chinese medicine(TCM)for the treatment of acute cerebral infarction(ACI),and provided ideas for the clinical treatment of ACI.Methods:The prescription composition data of randomized controlled clinical studies of TCM in the treatment of ACI from the establishment of China National Knowledge Infrastructure(CNKI),Wanfang Data,Chinese Science and Technology Journal Database(VIP),Chinese Biomedical Literature Database(CBM),and PubMed databases from to September 2022 were retrieved by computer.The Ancient and Modern Medical Records Cloud Platform(V2.3.5)was used to conduct data mining for the selected prescriptions,such as herbal medicine frequency statistics,property,flavors and attributive channel,herbal medicine efficacy statistics,correlation analysis,cluster analysis,and complex network analysis.Results:Through collection and screening,376 prescriptions meeting the criteria were included,involving 211 kinds of herbal medicines,with 3 729 times.The top 10 drugs were Chuanxiong,pheretima,angelica sinensis,astragalus membranaceus,salvia miltiorrhiza,carthamus tinctorius,pinellia ternata,semen persicae,gastrodia elata,and paeonia lactiflora.The four Qi were mainly warm and neutral.The five tastes were mainly bitter,sweet and pungent.The main channel was liver meridian.The drug effects were promoting blood circulation to remove blood stasis,relaxing the bowels,expelling wind and relieving pain,eliminating dampness and resolving phlegm,promoting blood circulation and promoting Qi circulation,and promoting blood circulation to dredge collaterals.Drug associations included"angelica-Chuanxiong","Chuanxiong-pheretima","astragalus-Chuanxiong"and so on.Herbal medicines clustering clustered 24 kinds of high-frequency herbal medicines which were used more than 40 times into 5 categories.Complex network analysis showed the core formula for the treatment of ACI were Chuanxiong,angelica,lumbricus,semen persicae,carthamus tinctorius,radix paeoniae rubra,radix astragali,radix salviae miltiorrhizae,and radix glycyrrhizae.Conclusion:TCM treatment of ACI is mainly based on included the pathogenesis of"blood stasis,phlegm,deficiency,and stagnation",focusing on the treatment both the symptoms and the causes,with priority for dredging,to apply both dredging and tonifying,promoting blood circulation,regulating Qi and activating blood circulation,supplementing Qi and activating blood circulation.
acute cerebral infarctiontraditional Chinese medicinemedication rulesdata mining
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NSTL
万方数据
