Objective:To investigate the effect of antihypertensive agents on the prognosis of patients with white coat hypertension(WCH).Methods:Literatures of the effects of antihypertensive agents on the prognosis of WCH patients were searched through PubMed,EMbase,the Cochrane Library and Web of Science databases.Two researchers independently evaluated the quality of the included literature and extracted the literature data.Meta-analysis was performed using RevMan 5.3 software.Results:A total of 8 literatures were included,involving 2 886 subjects,including 914 WCH patients taking antihypertensive drugs and 1 972 WCH patients without treatment with medicine.The average follow-up period ranged from 1.0 to 10.9 years.Meta-analysis showed that the incidence of cardiovascular events in WCH patients treated with antihypertensive drugs was higher than that in untreated WCH patients(RR= 1.67,95%CI 1.35-2.06,P<0.000 01).In subgroup analysis,the incidence of cardiovascular events in WCH patients≤60 years of age receiving antihypertensive therapy was lower than that in untreated WCH patients,but the difference showed no statistically significant(RR=0.90,95%CI 0.51-1.59,P =0.72).Conclusion:The available evidence suggests that the risk of cardiovascular events is not reduced in WCH patients who treated with antihypertensive agents.Due to the few studies included in this meta-analysis and the ambiguity of antihypertensive treatment,a large number of randomized controlled trials are still needed to confirm the effectiveness of antihypertensive treatment for WCH.
White coat hypertensionantihypertensive agentsthe risk of cardiovascular eventsprognosismeta-analysis
NETL
NSTL
万方数据
