Clinical Value of Contrast-enhanced Echocardiography Combined with Serum ADAMTS-4 and OPG in Evaluating the Degree of Coronary Artery Lesion in Patients with Coronary Heart Disease
Objective:To explore the clinical value of contrast-enhanced echocardiography combined with serum disintegrin-like and metalloproteinase with thrombospondin motifs-4(ADAMTS-4)and osteoprotegerin(OPG)for evaluating the degree of coronary artery lesion in patients with coronary heart disease.Methods:A total of 90 patients with coronary heart disease were enrolled as the study subjects.According to Gensini score,the patients were divided into coronary artery evere lesion group(30 cases),moderate lesion group(28 cases),and mild lesion group(32 cases).Contrast-enhanced echocardiography,serum ADAMTS-4 and OPG were detected in all patients.Quantitative parameters of contrast-enhanced echocardiography ultrasound(A value,βvalue),serum ADAMTS-4 and OPG values were compared among the 3 groups.Pearson correlation analysis was used to analyze the correlation between quantitative parameters of contrast-enhanced echocardiography,serum ADAMTS-4 and OPG levels,and Gensini score.Receiver operating characteristic curve(ROC)was drawn to assess the efficacy of quantitative parameters of contrast-enhanced echocardiography and serum ADAMTS-4 and OPG levels on severe coronary artery lesion.Results:The quantitative parameters A andβvalues of contrast-enhanced ultrasound in moderate lesion group and evere lesion group were lower than those in mild lesion group,and serum ADAMTS-4 and OPG levels were higher than those in mild lesion group,with statistical significance(P<0.05).The quantitative parameters A andβvalues of contrast-enhanced ultrasound in evere lesion group were lower than those in moderate lesion group,and serum ADAMTS-4 and OPG levels were higher than those in moderate lesion group,with statistical significance(P<0.05).Pearson correlation analysis showed that the A value and β value of contrast-enhanced echocardiography were negatively correlated with Gensini score(P<0.05),and the levels of serum ADAMTS-4 and OPG were positively correlated with Gensini score(P<0.05).ROC curve showed that the optimal cut-off values of A value,βvalue,serum ADAMTS-4,and OPG alone in the diagnosis of severe coronary artery lesion were 3.38,0.30,107.57 ng/mL,and 0.20 ng/mL,respectively.The corresponding areas under the curve(AUC)were 0.797,0.883,0.895,and 0.680,respectively.The combined diagnosis AUC of the four indexes was 0.937.Conclusion:The contrast-enhanced echocardiography quantitative parameters of A value,βvalue,ADAMTS-4,and OPG are correlated with the degree of coronary artery lesion in patients with coronary heart disease,and the combined detection shows a high application value for the evaluation of severe degree of coronary artery lesion.
coronary heart diseasecoronary artery lesioncontrast-enhanced echocardiographydisintegrin-like and metalloproteinase with thrombospondin motifs-4osteoprotegerin
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