Mechanism of"Different Diseases with Same Treatment"with Xingnaojing Injection for the Treatment of Acute Cerebral Infarction and Acute Cerebral Hemorrhage Based on Network Pharmacology
Objective:To explore the mechanism of"different diseases with same treatment"of Xingnaojing injection for treating acute cerebral infarction(ACI)and acute cerebral hemorrhage(ACH)by network pharmacology.Methods:The effective components and the targets of Xingnaojing injection were obtained by Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP)and Traditional Chinese Medicine Integrated Database(TCMID).The potential gene targets of ACI and ACH were obtained by GeneCards,OMIM,PharmGkb,TTD,and DrugBank.The common target Venn diagram was drawn by DIAGRAMS.The interaction network of"drugs-active ingredients-potential targets"was constructed by Cytoscape 3.9 software.Finally,the protein-protein interaction(PPI)network was constructed by STRING and topology analysis was carried out.Gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment of common targets were analyzed by R/BioConductor.Results:There were 68 active components of Xingnaojing injection,583 corresponding target genes,of which 3 597 potential targets were related to ACI,3 959 potential targets were related to ACH,and there were 299 common targets.PPI network core proteins included vascular endothelial growth factor A(VEGFA),JUN,signal transducers and activators of transcription 3(STAT3),interleukin(IL)-6,tumor necrosis factors(TNF),serum albumin(ALB),caspase-3(CASP3),protein kinase(AKT)1,mitogen activated protein kinase(MAPK)3,hypoxia-inducible factor-1α(HIF-1α),epidermal growth factor receptor(EGFR),epidermal growth factor(EGF),recombinant prostaglandin endoperoxide synthase 2(PTGS2),IL-1β,matrix metalloproteinase 9(MMP-9);mainly pathway involved in lipid and arteriosclerosis,MAPK signal pathway,fluid shear stress and arteriosclerosis,TNF signal pathway,apoptosis,IL-17 signal pathway and so on.Conclusion:Xingnaojing injection achieves the therapeutic effect on ACI and ACH by anti-oxidative stress,anti-inflammatory reaction,anti-apoptosis,and promoting angiogenesis.
acute cerebral infarctionacute cerebral hemorrhageXingnaojing injectionnetwork pharmacologydifferent diseases with same treatment
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