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急性心肌梗死病人中医证型与危险因素的关系

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目的:探究急性心肌梗死(AMI)不同中医证型与常见心血管病危险因素的相关关系。方法:回顾性分析 2014 年 1 月—2019年 12月在河南中医药大学第一附属医院心内科住院的 1 204 例 AMI病人临床资料。按照 AMI中医证型诊断标准将 1 204 例病人进行中医辨证分型,应用 SPSS软件统计描述各证型频数分布,以χ2 检验分析各证型间男女分布是否存在差异,单因素方差分析及非参数检验比较各证型在性别、年龄、体质指数(BMI)、住院天数及生化指标间的差异。二元 Logistic回归探究主要中医证型与各项指标的相关关系。结果:1 204例 AMI病人的中医证型分布依次为心肺气虚证(3。3%)<气虚血瘀证(3。4%)<气滞血瘀证(4。5%)<心阳虚衰证(7。3%)<痰浊瘀阻证(7。8%)<心血瘀阻证(18。6%)<气阴两虚证(24。1%)<痰浊壅塞证(31。0%);性别在 AMI各中医证型间分布差异有统计学意义;痰浊壅塞证发病年龄明显低于气阴两虚证、气虚血瘀证、气滞血瘀证、心阳虚衰证(P<0。05);气阴两虚证体重明显低于痰浊壅塞证、心血瘀阻证、痰浊瘀阻证(P<0。05);痰浊瘀阻证、痰浊壅塞证住院天数明显少于气阴两虚证(P<0。05);红细胞计数(RBC)、血红蛋白浓度(Hb)在痰浊壅塞证、心血瘀阻证明显高于气阴两虚证(P<0。05),而痰浊壅塞证与心血瘀阻证比较差异无统计学意义;舒张压(DBP)、三酰甘油(TG)在痰浊壅塞证明显高于气阴两虚证(P<0。05);痰浊壅塞证高密度脂蛋白胆固醇(HDL-C)明显低于气阴两虚证(P<0。05)。二元 Logistic回归显示,TG是痰浊壅塞证的独立危险因素,年龄、住院天数、HDL-C是AMI痰浊壅塞证的保护性因素;体重是 AMI痰浊瘀阻证的独立危险因素;体重、Hb则是AMI气阴两虚证保护性因素(P<0。05)。结论:性别、年龄、住院天数、RBC、体重、Hb、DBP、TG、HDL-C等指标在 AMI各中医证型间存在一定差异,并与 AMI主要中医证型存在一定的相关关系,可作为 AMI中医辨证分型及 AMI早期识别的临床参考。
Relationship between Traditional Chinese Medicine Syndrome Pattern and Risk Factors of Acute Myocardial Infarction
Objective:To explore the relationship between traditional Chinese medicine(TCM)syndrome types and cardiovascular risk factors of acute myocardial infarction(AMI).Methods:A total of 1 204 cases of AMI were analyzed retrospectively,SPSS software was used to describe the frequency distribution of each syndrome type,chi square test was used to test whether there were the distribution of mde and femde among each syndrome type,one-way ANOVA and nonparametric test were used to compare the differences of each syndrome type in gender,age,body mass index(BMI),days of hospital stay and biochemical indexes,and binary Logistic regression was used to explore the relationship between main TCM syndrome types and various indexes.Results:The distribution of TCM syndromes in 1 204 cases of AMI was as follows:heart and lung Qi deficiency syndrome(3.3%)<Qi deficiency and blood stasis syndrome(3.4%)<Qi stagnation and blood stasis syndrome(4.5%)<heart yang deficiency and failure syndrome(7.3%)<phlegm turbidity and blood stasis syndrome(7.8%)<heart pulse obstruction syndrome(18.6%)<Qi and Yin deficiency syndrome(24.1%)<phlegm turbidity congestion syndrome(31.0%).There were differences in gender distribution of TCM syndrome types of AMI.Age of onset:phlegm turbidity congestion syndrome was significantly lower than that of Qi and Yin deficiency syndrome,Qi Deficiency and Blood stasis syndrome,Qi stagnation and blood stasis syndrome,and heart yang deficiency and decline syndrome(P<0.05).Body weight:Qi and Yin deficiency syndrome was significantly lower than that of phlegm congestion syndrome,heart blood stasis syndrome,and phlegm turbidity and blood stasis syndrome(P<0.05).Days of hospital stay:phlegm turbidity and blood stasis syndrome and phlegm turbidity congestion syndrome were significantly less than that of Qi and Yin deficiency syndrome(P<0.05).Red blood cell count(RBC)and hemoglobin concentration(Hb):phlegm congestion syndrome and heart blood stasis syndrome were significantly higher than Qi and Yin deficiency syndrome(P<0.05),but there was no significant difference between phlegm congestion syndrome and heart blood stasis syndrome.Diastolic blood pressure(DBP)and triglyceride(TG):phlegm congestion was significantly higher than Qi and Yin deficiency syndrome(P<0.05).High density lipoprotein(HDL-C):the syndrome of phlegm turbidity obstruction was significantly lower than that of Qi and Yin deficiency(P<0.05).Binary Logistic regression showed that TG was an independent risk factor of phlegm congestion syndrome,and age,days of hospital stay,and HDL-C were protective factors of phlegm congestion syndrome of AMI.Body weight was an independent risk factor of phlegm turbidity and blood stasis syndrome of AMI,while body weight and Hb were protective factors of Qi and Yin deficiency syndrome in AMI(P<0.05).Conclusion:Gender,age,between of hospital stay,RBC,body weight,Hb,DBP,TG,HDL-C,and other indicators show certain differences between TCM syndrome types of AMI,and there are some relationship the main TCM syndrome types and AMI,which can be used as some clinical reference for TCM syndrome differentiation and early identification of AMI.

acute myocardial infarctiontraditional Chinese medicine syndrome typerisk factorscorrelation

包宇、卫靖靖、于瑞、刘子贤、郝鹏乐、朱明军

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河南中医药大学第一临床医学院(郑州 450000)

河南中医药大学第一附属医院(郑州 450000)

急性心肌梗死 中医证型 危险因素 相关性

国家自然科学基金重点项目

8203012

2024

中西医结合心脑血管病杂志
中国中西医结合学会 山西医科大学第一医院

中西医结合心脑血管病杂志

CSTPCD
影响因子:1.463
ISSN:1672-1349
年,卷(期):2024.22(3)
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