目的:通过可视化方法分析 Web of Science数据库中关于血管紧张素转化酶抑制剂(ACEI)治疗高血压领域的研究热点和趋势，以期为今后研究提供方向。方法:使用 Web of Science数据库进行检索，检索式为(((angiotensin converting enzyme inhibitors OR ACE inhibitors)OR ACEI))(Topic)AND hypertension(Topic)AND article OR review(Document Type)，检索时限 2010-2021年。通过 GraphPad Prism 8。02软件进行发文量趋势分析;运用 VOS-viewer软件进行合著分析(国家、机构)、共被引分析(作者、参考文献)和关键词共现分析。结果:共纳入 4 845 篇文献进行分析，结果显示近 12年的发文量以 2018 年最低(326 篇)，整体呈先降后升趋势;发文量最多的期刊是Hypertension(113 篇，2。33%);发文量最多的国家是美国(1 378 篇，28。44%);发文量最多的机构是Harvard University(133篇，2。75%);被引频次位居第 1位的作者是 Yusuf Salim(被引频次 1 399 次);质量较高的前 10 篇文献总被引频次高达 2 955 次;将出现频次超过 50次的 195个关键词进行聚类分析得出 4个方向:ACEI治疗高血压的作用机制、ACEI联合其他药物治疗高血压及并发症、ACEI治疗高血压的风险与预后、ACEI在肾性高血压中的应用。结论:目前美国在治疗高血压研究领域有重大影响力，研究内容包括 ACEI治疗高血压的作用机制、合并用药、高血压病的转归各个方面。未来的研究趋势是 ACEI药物应用于新型冠状病毒感染(COVID-19)状态下的安全性研究。
Bibliometric Analysis of Angiotensin Converting Enzyme Inhibitors for the Treatment of Hypertension
Objective:The research hotspots and trends of angiotensin-converting enzyme inhibitors(ACEI)for the treatment of hypertension in the database of Web of Science were analyzed by visualization method to provide direction for future research.Methods:The"(((angiotensin converting enzyme inhibitors OR ACE inhibitors)OR ACEI))(Topic)AND hypertension(Topic)AND article OR review(Document Type)using of the Web of Science database from 2010 to 2021 were searched.The trend of publication volume was analyzed by GraphPad Prism 8.02 software.VOS-viewer software was used to perform co-authorship analysis(country,institution),co-citation analysis(author,reference)and keyword co-occurrence analysis.Results:A total of 4 845 literatures were included for analysis.The results showed that the number of literatures published in the past 12 years was the lowest(326)in 2018,and the overall trend decreased and then increased.Hypertension(113 articles,2.33%)was the most publications.The country with the grentest number of articles was the United States(1 378 literatures,28.44%).The institution with the largest number of publications was Harvard University(133 literatures,2.75%).Yusuf Salim(1 399 citations)was the author with the first citation frequency.The top 10 literatures with high quality were cited 2 955 times.The cluster analysis of 195 keywords that appeared more than 50 times were the mechanism of action of ACEI in the treatment of hypertension,the combination of ACEI with other drugs in the treatment of hypertension and its complications,the risk and prognosis of ACEI in the treatment of hypertension,and the application of ACEI in renal hypertension.Conclusion:At present,the United States shows a significant influence for the treatment of hypertension,including the mechanism of action of ACEI in the treatment of hypertension,combined drug use,and the outcome of hypertension.The future research trend will be the ACEI safety study for the treatment of hypertensin with Corona Virus Disease 2019(COVID-19)infection.
万方数据
维普
