Effect and Safety of Shuxuetong Injection Combined with rt-PA Intravenous Thrombolysis on ACI:a Meta-analysis
Objective:To evaluate the effects of Shuxuetong injection combined with recombinant tissue plasminogen activator(rt-PA)intravenous thrombolysis on clinical total effective rate,neurological impairment,daily living ability,blood rheology and inflammatory factors in patients with acute cerebral infarction.Methods:The clinical randomized controlled trial(RCTs)of Shuxuetong injection combined with rt-PA intravenous thrombolysis for the treatment of acute cerebral infarction in Chinese Journal Full-text Database(CNKI),VIP database,Wanfang Database,Chinese Biomedical Literature Database(CBM),PubMed,the Cochrane Library,and Web of Science databases were searched.The search time was from self-built database to October 2022.Bias risk assessment was conducted according to Cochrane system assessment manual,and meta-analysis was conducted using RevMan 5.4 software.Results:Eight RCTs were included.Meta analysis showed that Shuxuetong injection combined with rt-PA intravenous thrombolysis could significantly improve the clinical total effective rate of patients with cerebral infarction compared with the control group(OR=3.60,95%CI 2.12-6.10,P<0.000 01),reduce the score of National Institutes of Health Stroke Scale(MD=-2.24,95%CI-2.92--1.55,P<0.000 01),improve the score of daily living ability(MD=10.28,95%CI 9.94-10.62,P<0.000 01),improve whole blood high tangent viscosity(MD=-0.61,95%CI-0.74--0.48,P<0.000 01),whole blood with low tangential viscosity(MD=-1.84,95%CI-2.06--1.61,P<0.000 01)and fibrinogen(MD=-0.72,95%CI-1.40--0.04,P =0.04),reduce C-reactive protein(SMD=-0.67,95%CI-0.99--0.35,P<0.000 1),tumor necrosis factor-α(SMD=-2.22,95%CI-4.35--0.09,P =0.04).In terms of safety,compared with the control group,the safety of experimental group was higher.Conclusion:Shuxuetong injection combined with rt-PA intravenous thrombolysis can improve the clinical total effective rate of acute cerebral infarction,improve nerve function deficit,daily living ability,blood rheology and inflammatory factors.
万方数据
维普
