Mechanism of Traditional Chinese Medicine for Treating Coronary Microvascular Diseases
Objective:To explore the characteristics of syndrome and treatment and the rule of drug use of traditional Chinese medicine in treating coronary microvascular disease(CMVD)based on literature,and to explore the mechanism of core drugs for treating CMVD by network pharmacology and molecular docking technology.Methods:CNKI,Wanfang,VIP,China Biomedical Literature Database,and PubMed were retrieved to collect the literature of TCM diagnosis and treatment of CMVD from the establishment of the database to November 1,2022.The classification and statistical analysis of TCM syndromes and treatment principles were conducted,and the core drug pairs were mined.TCMSP,GeneCards,DisGeNET,TTD,OMIM,STRING,Metascape database,and Cytoscape software were used to analyze the interaction between core drug pairs and diseases and related pathways.Finally,molecular docking technology was used to verify the docking between core chemical components and key targets.Results:One hundred and sixty papers were screened to meet the requirements.The TCM syndrome type of CMVD was mainly Qi deficiency and blood stasis,involving 89 drugs.The drug pair with the highest support was Astragalus membranaceus-Salvia miltiorrhiza.Quercetin,luteolin,kaempferol,isorhamnetin and other components in Astragalus membranaceus-Salvia miltiorrhiza can affect advanced glycation endproducts(AGE)-receptor for AGE(RAGE)signaling pathway in diabetic complications,hypoxia-inducible factor(HIF)-1,nuclear factor-KB(NF-KB)and other signal pathways to interfere with CMVD by acting on interleukin 6(IL6),Caspase-3(CASP3),hypoxia-inducible factor 1-alpha(HIF1 A),peroxisome proliferator-activated receptor gamma(PPARG),and other targets.The results of molecular docking showed that the key active components were well docked with the target.Conclusion:The treatment of CMVD with traditional Chinese medicine is mainly to invigorate Qi and promote blood circulation.The potential mechanism of its core drug for the treatment of CMVD with"Astragalus membranaceus-Salvia miltiorrhiza"may be related anti-inflammatory reaction,improving oxidative stress,and regulating apoptosis.
coronary microvascular diseasetraditional Chinese medicinediagnosis and treatment regularitynetwork pharmacologymolecular dockingAstragalus membranaceusSalvia miltiorrhiza
万方数据
维普
