Mendelian Randomization Study on the Causal Relationship between Atrial Fibrillation and Malignant Neoplasm of Intestinal Tract
Objective:To explore the causal nexus between atrial fibrillation(AF)and malignant neoplasm of intestinal tract.Methods:By univariable Mendelian randomization(MR)coupled with genome-wide association studies(GWAS)involving over one million participants from six pertinent GWAS,single nucleotide polymorphisms(SNPs)associated with AF were identified.The inverse-variance weighted(IVW)method was the principal analytical approach for the MR analysis.Results:Univariable MR unveils a conspicuous causal association between the hereditary predisposition to AF and an elevated risk of colorectal malignancies(OR=1.12,95％Cl 1.00-1.25,P=0.043)as well as small intestine malignancies(OR=1.34,95％Cl 1.04-1.74,P=0.025).Conclusion:This study elucidates a latent causal relationship between the hereditary susceptibility to AF and gastrointestinal malignancies,providing reference for the treatment and prevention of cardiovascular diseases and tumors of the digestive tract.
atrial fibrillationmalignant neoplasm of intestinal tractMendelian randomization
万方数据
维普
