Hengqing Ⅳ Prescription Combined with Levodopa and Benserazide Hydrochloride Tablets for the Treatment of Parkinson's Disease
Objective:To observe the clinical efficacy of Hengqing Ⅳ Prescription combined with levodopa and benserazide hydrochloride tablets for the treatment of Parkinson's disease(PD)patients.Methods:PD patients admitted to Shanghai Sixth People's Hospital from January 2020 to December 2022 were randomly divided into control group and observation group by random number table method.The patients in control group were treated with levodopa and benserazide hydrochloride tablets,while the patients in observation group were treated with Hengqing Ⅳ Prescription combined with levodopa and benserazide hydrochloride tablets.The course of treatment of the both groups was 12 weeks.After treatment,efficacy was evaluated,and the Unified Parkinson's Disease Rating Scale(UPDRS),Parkinson's Disease questionnaire(PDQ-39),cerebral blood flow,gait,and levels of serum tumor necrosis factorα(TNF-α),interleukin(IL)-6,superoxide dismutase(SOD),malondialdehyde(MDA),glutathione peroxidase(GSH-Px),brain derived neurotrophic factor(BDNF),glutamic acid(Glu),and γ-aminobutyric acid(GABA)were assayed before and after treatment.Results:The therapeutic effect of the observation group was significantly superior to that of the control group(88.71％and 60.66％,P＜0.05).Compared with data before treatment,UPDRS score and PDQ-39 score of the both groups of patients decreased significantly after treatment,while the stride length,stride speed,cerebral blood flow,and turning angular velocity increased significantly(P＜0.05 or P＜0.01).Compared with control group,UPDRS score and PDQ-39 score of observation group patients were significantly reduced,while stride length,stride speed,cerebral blood flow,and turning angle speed were significantly increased(P＜0.05).Compared with data before treatment,the levels of the serum TNF-α,IL-6,and MDA of patients in observation group after treatment decreased,while the levels of SOD,GSH-Px,BDNF,Glu,and GABA increased(P＜0.05 or P＜0.01).Compared with control group,the levels of serum TNF-α,IL-6,and MDA in observation group decreased,while the levels of SOD,GSH-Px,BDNF,Glu,and GABA increased(P＜0.05).Conclusion:The therapeutic effect of Henqing Ⅳ prescription combined with levodopa and benserazide hydrochloride tablets is better than that of levodopa and benserazide hydrochloride tablets alone for the treatment of PD,which can reduce the levels of serum TNF-a,IL-6 and MDA,and increase the levels of serum SOD,GSH-Px,BDNF,Glu,and GABA in PD patients.
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