Correlation between Serum MCP-1,GDF-15,GMP-140 and Degree of Coronary Artery Stenosis in Elderly Patients with Coronary Heart Disease
Objective:To analyze the correlation between serum levels of monocyte chemoattractant protein-1(MCP-1),growth differentiation factor-15(GDF-15),and platelet granular membrane protein-140(GMP-140)and the severity of coronary artery stenosis in elderly patients with coronary heart disease.Methods:Ninety-seven elderly patients with coronary heart disease admitted to General Hospital of the Western Theater Command of People's Liberation Army from March,2022 to March,2023,and 60 healthy people in the same period were selected and included in coronary heart disease group and control group respectively.Serum MCP-1,GDF-15,and GMP-140 were detected.According to the degree of coronary artery stenosis,patients with coronary heart disease were divided into mild stenosis group and severe stenosis group,and the differences of serum levels of MCP-1,GDF-15,and GMP-140 between the two groups were compared.Spearman correlation analysis was used to calculate the correlation between serum MCP-1,GDF-15,and GMP-140 and the degree of coronary artery stenosis,and receiver operating characteristic curve(ROC)was used to analyze the efficacy of MCP-1,GDF-15,and GMP-140 for evaluating the degree of coronary artery stenosis.Results:Serum MCP-1,GDF-15,and GMP-140 in coronary heart disease group were higher than those in control group,and the difference was statistically significant(P＜0.05).Serum MCP-1,GDF-15,and GMP-140 in severe stenosis group were higher than those in mild stenosis group,and the difference was statistically significant(P＜0.05).Spearman correlation analysis showed that serum MCP-1,GDF-15,and GMP-140 were positively correlated with the degree of coronary artery stenosis(P＜0.05).ROC curve showed that the area under the curve(AUC)of MCP-1,GDF-15,and GMP-140 combined for evaluating the degree of coronary artery stenosis was 0.887,and the sensitivity and specificity were 88.89％and 88.46％respectively.Conclusion:Serum levels of MCP-1,GDF-15,and GMP-140 significantly increased in patients with coronary heart disease,and the elevation of these indexs is closely associated with the progression of coronary artery stenosis.The detection of serum MCP-1,GDF-15,and GMP-140 can provide a reliable reference for evaluating the degree of coronary artery stenosis.
万方数据
维普
