The Correlation between Dialectical Classification of Ischemic Stroke and MRI Lesion Site:a Meta-analysis
Objective:To systematically evaluate the correlation between dialectical classification of ischemic stroke and the lesion site of magnetic resonance imaging(MRI)in order to improve the objective understanding of traditional Chinese medicine(TCM)syndrome differentiation.Methods:All literatures on correlation between ischemic stroke syndrome differentiation and MRI features from CNKI,WanFang Database,VIP Chinese Journal Database and CBM were searched by computer,and literatures meeting the inclusion and exclusion criteria were screened.The search period was from the establishment of the database to June 30,2021,and the literature quality evaluation and data extraction were carried out.Review Manager 5.4 software was used for Meta-analysis.Results:A total of 9 literatures were included,and the detection rates of MRI lesions were different for different TCM syndrome types of ischemic stroke.Cerebral lobe group:Qi-deficiency and blood-stasis syndrome compared with other syndrome types(OR=3.58,95%CI 1.92-6.65,P<0.0001),and wind-phlegm bstruction syndrome compared with other syndrome types(OR=0.45,95%CI 0.29-0.79,P =0.006)had statistical significance.Basal ganglia group:wind-phlegm obstruction syndrome compared with other syndrome types(OR=4.08,95%CI 1.96-8.50,P =0.0002),Qi-deficiency and blood-stasis syndrome with other syndrome types(OR=0.25,95%CI 0.11-0.54,P =0.0004),syndrome of phlegm-heat fu-organs with other syndrome compared with other syndrome types(OR=0.27,95%CI 0.14-0.50,P<0.0001),Yin deficiency wind syndrome compared with other syndrome types(OR=0.61,95%CI 0.39-0.97,P =0.04)had statistical significance.Brain stem group:syndrome of phlegm-heat fu-organs with other syndrome compared with other syndrome types(OR=3.04,95%CI 1.79-5.08,P<0.0001),and Yin deficiency wind syndrome compared with other syndrome types(OR=2.18,95%CI 1.30-3.66,P =0.003)had statistical significance.In cerebellar group:Yin deficiency wind syndrome compared with other syndrome types(OR=2.84,95%CI 1.05-7.71,P =0.04)had statistical significance.Conclusion:The current evidence showed that the TCM syndrome differentiation of ischemic stroke was correlated with the lesion site of MRI,which could provide a certain reference for clinical TCM syndrome differentiation and classification of ischemic stroke,but the above results still needed to be further verified by large samples and multi-center studies
ischemic strokemagnetic resonance imagingtraditional Chinese medicine syndrome differentiationMeta-analysis
NETL
NSTL
万方数据
维普
