Shugan Jieyu Therapy for the Treatment of Coronary Heart Disease with Depression:Meta-analysis and GRADE Evaluation
Objective:To evaluate the efficacy and safety of Shugan Jieyu therapy for the treatment of coronary heart disease complicated with depression.Methods:Computer retrieved datas from the self-built database up to October 2022.Chinese databases included Chinese Medical Literature Database,VIP database,Chinese Journal Full-text Database,WanFang Database.English databases included PubMed,the Cochrane Library and Web of Science.Meta-analysis was performed based on the included outcome indicators of traditional Chinese medicine(TCM)syndrome score,effective rate(angina pectoris effective rate,electrocardiogram effective rate,depression effective rate),depression scale score[Self-rating Depression Scale(SDS),Hamilton Depression Scale(HAMD)],and C-reactive protein(CRP).The evidence quality of TCM syndrome score,effective rate and depression scale score were evaluated.Results:A total of 22 literatures were included,involving 1 828 patients.Compared with conventional western medicine treatment,combined use of TCM for Shugan Jieyu could significantly reduce the TCM syndrome score of patients(SMD=-0.89,95%CI-1.20--0.58,P<0.000 01),improved the effective rate of angina pectoris(RR=1.29,95%CI 1.23-1.36,P<0.000 01)and ECG response rate(RR=1.21,95%CI 1.08-1.36,P =0.001),improved depression response rate(RR=1.50,95%CI 1.33-1.71,P<0.000 01),decreased HAMD score(SMD=-2.17,95%CI-2.90--1.44,P<0.000 01),SDS score(SMD=-1.73,95%CI-2.33--1.13,P<0.000 01)and CRP level(SMD=-1.81,95%CI-2.06--1.55,P<0.000 01),and there were no obvious adverse reactions.GRADE rating results showed that the evidence quality of TCM syndrome scores were low,the effective rate of angina pectoris and depression were moderate,and the effective rate of electrocardiogram,HAMD and SDS score were low.Conclusion:The existing evidence shows that the method of Shugan Jieyu therapy can effectively improve the clinical symptoms of patients with coronary heart disease complicated with depression,and with high safety.
万方数据
维普
