摘要
目的:基于数据挖掘方法,对国家专利口服复方治疗冠心病的组方用药规律进行分析,以期为冠心病的中医临床调治及新药新方研发提供参考依据.方法:检索并录入国家知识产权局从2018年1月-2022年12月治疗冠心病的口服专利复方数据,并录入到Excel表格中作为数据源.基于此数据源按要求进行筛选,建立符合要求的数据库.运用IBM SPSS Modeler、IBM SPSS Statistics、Cytoscape等软件对中药的使用频次、药物功效、性味归经、关联规则等进行分析,并对关联强度较高的中药进行聚类分析.结果:共纳入184首口服治疗冠心病的专利复方,总计含有中药322味,其中出现频次≥20次的中药共有30味,排名前3位的药物为丹参、川芎、黄芪,中药功效多为益气、滋阴、活血化瘀、祛痰、清热等,四气以温、寒、平常见,五味以甘、苦、辛居多,归经多属肝、心、脾经.高频药物进行关联规则分析后得出24组药物组合,聚类分析获得3组有效聚类方.结论:虚、热、瘀、痰是冠心病发病关键,病位在心、肝、脾,治疗应注重益气养阴、活血化瘀,辅以清热、化痰等.临证时应注重辨证论治,把握关键治法.
Abstract
Objective:Based on the data mining method to analyze the drug use rule of the national patent oral compound prescription for the treatment of coronary heart disease.Methods:The data of the oral patent compound used by the State Intellectual Property Office for the treatment of coronary heart disease from January 2018 to December 2022 were retrieved and entered into Excel tables as data sources.Based on this data source,filter according to the requirements,and built a database that meets the requirements.IBM SPSS Modeler,IBM SPSS Statistics,Cytoscape,and other software were used to analyze the frequency of use,drug efficacy,taste menstruation,association rules,and so on.Cluster analysis was carried out for Chinese medicines with high correlation intensity.Results:A total of 184 patented compounds for oral treatment of coronary heart disease were included,including 322 flavors of traditional Chinese medicine.There were 30 herbs with frequency≥20,and the top 3 were Danshen,Chuanxiong and Huangqi.The effect of traditional Chinese medicine were mainly to Yi Qi,Zi Yin,promoting blood circulation and removing blood stasis,expectorant,clearing heat.The four properties were warm,cold.The five tastes were sweet,bitter and xin.Most of the meridian tropism belonged to liver,heart and spleen.After association rule analysis,24 groups of drug combinations were obtained,and 3 groups of effective clustering prescriptions were obtained by cluster analysis.Conclusion:Deficiency,heat,blood stasis,and phlegm are the key pathogenesis of coronary heart disease.The disease is located in the heart,liver and spleen.The treatment should pay attention to replenishing Qi and nourishing Yin,promoting blood circulation and removing blood stasis,supplemented by clearing heat and resolving phlegm.Clinical treatment,should pay attention to syndrome differentiation and treatment,and grasp the key treatment methods.
基金项目
国家重点研发计划(2017YFC1700400)
国家重点研发计划(2017YFC1700401)
全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号)
国家自然科学基金面上项目(81273698)
辽宁省特聘教授滚动支持项目(辽教函[2018]35号)
维普
万方数据