Effects of Huoxin Pill on Serum GDF-15,ESM-1,sST2 Levels,and Cardiac Function in Patients with Acute Myocardial Infarction
Objective:To observe the effects of Huoxin Pill on the levels of serum growth differentiation factor-15(GDF-15),endothelial cell specific molecule-1(ESM-1),soluble oncogenic inhibitory factor 2(sST2),and cardiac function in patients with acute myocardial infarction.Methods:A total of 94 patients with acute myocardial infarction were randomly divided into control group and treatment group,with 47 cases in each group.The control group was treated with aspirin tablets,ticagrelor tablets,atorvastatin calcium tablets,metoprolol tartrate tablets,and the treatment group was treated with Huoxin pill based on the treatment of control group.The clinical efficacy,cardiac function,cardiac enzyme spectrum indexes,serum GDF-15,ESM-1,sST2 levels,quality of life,and adverse reactions were compared between the two groups.Results:After 2 weeks of treatment,the total effective rate in the treatment group was 93.62％,that was 78.72％in the control group,and the difference was statistically significant(P＜0.05).After 2 weeks of treatment,the levels of left ventricular mass index(LVMI),left ventricular remodeling index(LVRI)and serum myocardial troponin l(cTnl),creatine kinase isoenzyme(CK-MB),creatine kinase(CK),GDF-15,ESM-1,and sST2 in both groups decreased compared with those before treatment(P＜0.05),and the reduction degree of treatment group was better than that of the control group(P＜0.05).After 2 weeks of treatment,left ventricular ejection fraction(LVEF)and Seattle Angina Scale(SAQ)score in both groups were higher than those before treatment(P＜0.05),and the degree of increase in the treatment group were better than that in the control group(P＜0.05).The 6 min walking distance in both groups were longer than that before treatment(P＜0.05),and the 6 min walking distance in treatment group was longer than that in the control group(P＜0.05).There was no significant difference in the total incidence of adverse reactions between treatment group and control group(8.51％and 14.89％,P＞0.05).Conclusion:In the treatment of patients with acute myocardial infarction,Huoxin pill can reduce the levels of serum GDF-15,ESM-1,sST2,and cardiac enzyme spectrum indexes,improve cardiac function and quality of life,and improve clinical efficacy with better safety.
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