Objective:To find lipid parameters that were more sensitive for predicting the risk of type 2 diabetes(T2DM)complicated with coronary heart disease(CHD),so as to provide more powerful parameters and theoretical support for clinical prediction of CHD in patients with T2DM.Methods:A total of 303 patients with T2DM were enrolled and divided into two groups according to the results of coronary angiography:T2DM alone group(150 cases)and T2DM combined with CHD group(153 cases).The general clinical data and laboratory indicators of the two groups were recorded,and the non-traditional lipid parameters were calculated according to the traditional blood lipid parameters.The correlation between non-traditional lipid parameters and T2DM combined with CHD was evaluated by Logistic regression analysis.Results:Compared with the T2DM group alone,the traditional blood lipid parameter HDL-C level in the T2DM complicated with CHD group was lower(P<0.05).However,non-traditional lipid parameters,such as TC/HDL-C,LDL-C/HDL-C,and AIP were higher in the T2DM and CHD group than that in the T2DM group alone(P<0.05).In univariate Logistic regression analysis,HDL-C was the protective factor for T2DM complicated with CHD(OR=0.191),while the traditional lipid parameters LDL-C/HDL-C(OR=1.376),AIP(OR=2.215)and LCI(OR=1.009)were the risk factors for T2DM complicated with CHD.Further multivariate Logistic regression analysis showed that HDL-C was an independent protective factor for T2DM and CHD(OR=0.077),while the non-traditional lipid parameter LCI was independently positively correlated with T2DM and CHD(OR=1.023),which was an independent risk factor for T2DM and CHD.The receiver operator characteristic(ROC)curves showed that the area under the cure(AUC)of HDL-C,TC/HDL-C,LDL-C/HDL-C,and AIP were 0.386,0.601,0.578,and 0.572,respectively,and the prediction ability of non-traditional lipid indexes was stronger than that of traditional lipids.At the same time,the AUC of HDL-C,LDL-C/HDL-C,and AIP with differences in LCI combined with univariate Logistic regression analysis increased,indicating that the combined detection of traditional HDL-C and non-traditional lipid parameters further improved the diagnostic performance of T2DM complicated with CHD.Conclusion:HDL-C,LDL-C/HDL-C,AIP,and LCI is the influencing factors of T2DM complicated with CHD.LCI is positively correlated with T2DM concurrent CHD.The predictive ability of non-traditional lipid indexes for CHD in patients with T2DM is stronger than that of traditional blood lipid parameters,and the combined detection of traditional HDL-C and non-traditional lipid parameters will further improve the diagnostic efficiency of T2DM complicated with CHD.
type 2 diabetescoronary heart diseasenon-traditional lipid parameters
NETL
NSTL
万方数据
