The Rule of Traditional Chinese Medicine for Treating Tachyarrhythmia and Bradyarrhythmia Based on Data Mining
Objective:To explore the rule of traditional Chinese medicine(TCM)for the treatment of tachyarrhythmia and bradyarrhythmia to provide data basis of clinical drug use.Methods:The literatures of TCM in the treatment of tachyarrhythmia and bradyarrhythmia were searched from China National Knowledge Infrastructure(CNKI),Wanfang Database,Vipnet and SinoMed.The search time were from January 1,1998 to December 31,2022.Excel 2016 software was used to establish prescription data tables.TCM Inheritance Computing Platform V3.0 was used for analysis.Results:A total of 855 prescriptions for tachyarrhythmia and 431 prescriptions for bradyarrhythmia were included.The high frequency TCM for tachyarrhythmia were salvia miltiorrhiza,ophiopogon japonicus,astragalus membranaceus,and semen ziziphi Spinosae,etc.The high frequency TCM for the treatment of bradyarrhythmia were licorice,aconite,ramulus cinnamomi,astragalus membranaceus,and salvial miltiorrhiz,etc.In terms of efficacy,tonic drugs and drugs for activating blood circulation and removing blood stasis were used populary.Heat clearing drugs and tranquilizing drugs accounted for a high proportion for the treatment of tachyarrhythmia.In the treatment of bradyarrhythmia,the proportion of drugs for relieving exterior cold and dispelling cold and warming internal organs were used popularly.The TCM for tachyarrhythmia were mainly bitter cold and sweet warm,while the TCM for bradyarrhythmia were mainly sweet warm and pungent warm.The meridian tropism were closely related to heart,lung,spleen,liver,and kidney.The drug combination pattern analysis showed that the use frequency of glycyrrhiza-radix salviae were higher in both types.Glycyrrhiza-radix ophiopogonis were more common in the treatment of tachyarrhythmia.Glycyrrhiza-radix aconiti and glycyrrhiza-ramulus cinnamomi were more common in the treatment of bradyarrhythmia.Association rule analysis showed that the highest confidence combinations for tachyarrhythmia were ophiopogon japonicus,ramulus cinnamomi,glycyrrhiza uralensis,and for bradyarrhythmia were glycyrrhiza uralensis,asarum,ephedra,aconite.Four core prescriptions were obtained by K-means cluster analysis.Conclusion:Tachyarrhythmia and bradyarrhythmia are both diseases of deficiency in origin and excess in symptoms.The common pathogenesis are"deficiency"and"blood stasis",tachyarrhythmia more"Yin deficiency"and"heat",bradyarrhythmia more"Yang deficiency"and"cold".The common treatment method is"invigorating Qi and activating blood circulation".The common core Chinese medicines are licorice and salvia miltiorrhiza.On this basis,the tachyarrhythmia uses drug pairs and prescriptions with the effects of nourishing Yin,clearing heat,calming nerves and calming nerves,and bradyarrhythmia uses drug pairs and prescriptions with the effects of warming Yang and restoring pulse,strengthening spleen and replenishing Qi.
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