Effect of Xuefu Zhuyu Decoction on Inflammation Indicators,Cardiac Function and Quality of Life after PCI in STEMI Patients
Objective:To investigate the effects of Xuefu Zhuyu decoction on inflammation indicators,cardiac function and quality of life after percutaneous coronary intervention(PCI)in ST segment elevation myocardial infarction(STEMI)patients.Methods:A total of 244 STEMI patients after PCI were selected as the study subjects and randomly divided into experimental group and control group,with 122 cases in each group.The experimental group received Xuefu Zhuyu decoction+routine basic treatment alone after PCI,while the control group received routine basic treatment alone after PCI.Both groups were followed up for 6 months.The occurrence of major cardiovascular and cerebrovascular adverse events(MACCE),myocardial Infarction Multidimensional Scale(MIDAS)score,New York Heart Association(NYHA)cardiac function grade,adverse reaction occurrence,clinical symptom score of traditional Chinese medicine(TCM),TCM syndrome efficacy,left ventricular remodeling index,and inflammatory factor level[interleukin-6(IL-6),endothelin-1(ET-1),nitric oxide(NO),and matrix metalloproteinase-9(MMP-9)]in the two groups were analyzed and compared before and after treatment.Results:After treatment,the total incidence of MACCE in the experimental group was lower than that in the control group,the improvement of NYHA cardiac function grade was better than that in the control group,and the curative effect of TCM syndrome was higher than that in the control group(P<0.05).After treatment,MIDAS scores in both groups were lower than that before treatment,and that in the experimental group was lower than that of the control group(P<0.05).After treatment,TCM symptom scores of both groups were lower than that before treatment,and that the experimental group was lower than that of the control group(P<0.05).After treatment,left ventricular end-systolic diameter(LVESD)and left ventricular end diastolic diameter(LVEDD)decreased and left ventricular ejection fraction(LVEF)increased in the two groups,and LVESD and LVEDD in the experimental group were lower than those in the control group,while LVEF was higher than that in the control group(P<0.05).After treatment,IL-6,ET-1 and MMP-9 decreased and NO increased in both groups,and IL-6,ET-1 and MMP-9 in the experimental group were lower than those in the control group,and NO were higher than those in the control group(P<0.05).Conclusion:The application of Xuefu Zhuyu decoction in STEMI patients after PCI can significantly improve overall survival quality,reduce the risk of MACE occurrence,improve cardiac function,and alleviate inflammatory reactions,which are beneficial for patient prognosis.
acute myocardial infarctionpercutaneous coronary intervention therapyXuefu Zhuyu decoctioncardiac functionquality of life
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