Mechanism of Qishen Taohong Granules for the Treatment of Chronic Heart Failure Based on Network Pharmacology and Molecular Docking
Objective:To explore the mechanism of Qishen Taohong granules for the treatment of chronic heart failure based on network pharmacology and molecular docking.Methods:The active constituents and targets of Qishen Taohong granules were screened by TCMSP.The standard gene name of the target was obtained by UniProt.GeneCards and OMIM were used to obtain chronic heart failure related targets.After obtaining common targets for drugs and diseases,with STRING protein-protein interaction(PPI)network diagram was drawed.Metascape was used for gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis.AutoDock was used for molecular docking verification.Results:Qishen Taohong granules mainly involved 6 key components such as quercetin and kaferol,and 34 key targets such as hypoxia-inducing factor-1α(HIF1A)and tumor necrosis factor(TNF)which acted on chronic heart failure.There were 20 key pathways including nuclear factor κB(NF-κB)pathway and phosphatidylinositol 3-kinase/protein kinase B(PI3K/AKT)signaling pathway.Conclusion:Qishen Taohong granules regulated chronic heart failure mainly through PI3K/AKT pathway,vascular endothelial growth factor(VEGF)pathway,NF-κB pathway,forkhead box protein O(FoxO)pathway,insulin resistance,lipids and atherosclerosis.The main regulatory mechanisms included apoptosis,inflammatory response,oxidative stress,myocardial remodeling,insulin resistance,and lipid metabolism.
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