慢性心力衰竭病人发生认知功能障碍的影响因素分析
Analysis of Influencing Factors of Cognitive Dysfunction in Patients with Chronic Heart Failure
褚国洁 1张立晶 2王承龙1
作者信息
- 1. 中国中医科学院西苑医院(北京 100091)
- 2. 北京中医药大学东直门医院
- 折叠
摘要
目的:分析慢性心力衰竭病人发生认知功能障碍的临床特点及影响因素.方法:选取2020年12月-2021年12月北京中医药大学东直门医院收治的慢性心力衰竭病人,根据蒙特利尔认知评估(MoCA)量表和简易精神状态评估(MMSE)量表评分将并发认知功能障碍的114例病人作为认知障碍组(A组)、未并发认知功能障碍的78例病人作为认知正常组(B组).比较两组临床资料,通过多因素二元Logistic回归分析慢性心力衰竭病人发生认知功能障碍的影响因素.结果:A组年龄、纽约心脏病协会(NYHA)心功能分级、氨基末端B型脑钠肽前体(NT-proBNP)、同型半胱氨酸(Hcy)、胱抑素C(CysC)水平均高于B组,受教育程度、血红蛋白(Hb)、左室射血分数(LVEF)均低于B组(P＜0.05).多因素二元Logistic回归分析结果显示:年龄、受教育程度、LVEF、Hcy、NT-proBNP是慢性心力衰竭病人发生认知功能障碍的独立危险因素(P＜0.05).结论:高龄、受教育程度低、Hcy升高、NT-proBNP升高及LVEF降低是慢性心力衰竭病人发生认知功能障碍的独立危险因素.
Abstract
Objective:To analyze the clinical characteristics and influencing factors of cognitive dysfunction in patients with chronic heart failure.Methods:Patients with chronic heart failure from December 2020 to December 2021 were selected.According to the scores of Montreal Cognitive Assessment(MoCA)scale and Mini-mental State Examination(MMSE)scale,114 patients with concurrent cognitive impairment were classified as cognitive impairment group(A group)and 78 patients without concurrent cognitive impairment were classified as cognitive normal group(B group).The clinical data between two groups were compared.The influencing factors of cognitive dysfunction in patients with chronic heart failure were analyzed by multivariate binary Logistic regression.Results:Age,New York Heart Association(NYHA)cardiac function grade,amino terminal B-type brain natriuretic peptide precursor(NT-proBNP),homocysteine(Hcy)and cystatin C(CysC)levels in the A group were higher than those in the B group,and education level,hemoglobin(Hb),and left ventricular ejection fraction(LVEF)were lower than those in the B group(P＜0.05).Multivariate Logistic regression analysis showed that age,educated level,LVEF,Hcy and NT-proBNP were independent risk factors related cognitive dysfunction in patients with chronic heart failure(P＜0.05).Conclusion:Advanced age,low educated level,elevated Hcy,elevated NT-proBNP and reduced LVEF were independent risk factors related cognitive dysfunction in patients with chronic heart failure.
关键词
慢性心力衰竭/认知功能障碍/临床特点/危险因素Key words
chronic heart failure/cognitive dysfunction/clinical characteristics/risk factors引用本文复制引用
基金项目
国家自然科学基金面上项目(81874410)
出版年
2024
NETL
NSTL
万方数据