Benefiting Qi,Nourishing Yin and Dissolving Stasis for the Treatment of Medium-to-high Risk Atrial Fibrillation in Patients with Deficiency of Qi and Yin Concurrent Blood Stasis
Objective:To observe the clinical efficacy and safety of benefiting Qi,nourishing Yin and dissolving Stasis for the treatment of medium-to-high risk atrial fibrillation in patients with deficiency of Qi and Yin concurrent blood stasis.Methods:Ninety patients with atrial fibrillation were divided into the control group(28 cases)and the observation group(56 cases)by random number table according to 1:2.The patients of control group were treated with basic western medicine treatment for 24 weeks,and the patients of observation group were treated with basic western medicine treatment combined with Fumai Anxin formula for 24 weeks.Traditional Chinese medicine syndrome scores,serum stroke indicators[thyrotropin(TSH),insulin-like growth factor 1(IGF-1)],inflammatory factors[hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)]thrombosis factors[von Willebrand factor(vWF)],D-dimer(D-D),P-selectin(GMP-140),and related safety indicators were compared between the two groups.Results:At the 12th week and 24th week of treatment,the traditional Chinese medicine syndrome score of the observation group was less than that before treatment(P＜0.05),and the traditional Chinese medicine syndrome score of the observation group was less than that of the control group(P＜0.05).At the 12th week of treatment,the scores of chest tightness and night sweat in the observation group were less than those in the control group(P＜0.05).At the 24th week of treatment,the scores of chest tightness,fatigue,shortness of breath and night sweat in the observation group were less than those in the control group(P＜0.05).At the 24th week of treatment,the levels of TSH and IGF-1 in the observation group were less than those in the control group(P＜0.05).At the 24th week of treatment,the levels of hs-CRP,IL-6,vWF,D-D,and GMP-140 in the observation group were better than those in the control group(P＜0.05).There was no significant difference in safety indexes between the two groups before and after treatment(P＞0.05).Conclusion:Benefiting Qi,nourishing Yin and dissolving stasis for the treatment of medium-to-high risk atrial fibrillation in patients with deficiency of Qi and Yin concurrent blood stasis could improve the traditional Chinese medicine syndrome score and improve the symptoms of atrial fibrillation,its mechanism might relate decreasing the levels of thrombosis and inflammatory factors.
atrial fibrillationdeficiency of both Qi and Yin concurrent blood stasisbenefiting Qi,nourishing Yin and dissolving stasisFumai Anxin formulainflammatory factorsstroke risk
万方数据
维普
