首页|龙生蛭胶囊治疗气虚血瘀型眩晕的临床研究

龙生蛭胶囊治疗气虚血瘀型眩晕的临床研究

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目的:观察龙生蛭胶囊治疗气虚血瘀型眩晕的临床疗效。方法:将纳入的200例气虚血瘀型眩晕病人随机分为研究组、对照组，每组100例。对照组口服盐酸氟桂利嗪(西比灵)治疗，研究组在对照组基础上加用龙生蛭胶囊治疗，两组均维持治疗4周。观察两组治疗前后脑血流动力学、血液流变学、中医证候积分变化，比较两组临床疗效，观察两组不良反应发生情况。结果:研究组临床疗效总有效率明显高于对照组，差异有统计学意义(93。0％与85。0％，P＜0。05)。治疗后，两组脑血流动力学、血液流变学指标均较治疗前明显改善，且治疗后研究组脑血流动力学、血液流变学指标明显优于对照组，差异均有统计学意义(P＜0。05)。治疗后，两组中医证候各项评分均低于治疗前，且研究组明显低于对照组，差异均有统计学意义(P＜0。05)。研究期间两组均未出现明显的不良反应。结论:龙生蛭胶囊治疗气虚血瘀型眩晕，可改善气虚血瘀型眩晕相关的临床症状，可能与其可改善气虚血瘀型眩晕病人脑血流动力学、血液流变学有关。
Clinical Study of Longshengzhi Capsules for Treating Vertigo of Qi Deficiency and Blood Stasis
Objective:To observe the clinical efficacy of Longshengzhi capsules for treating vertigo of Qi deficiency and blood stasis.Methods:Two hundred vertigo patients with Qi deficiency and blood stasis were randomly divided into study group and control group,with 100 cases in each group.The patients of control group were treated with oral sibiline for 4 weeks,and the patients of study group were treated with Longshengzhi capsules on the basis of the control group for 4 weeks.The cerebral hemodynamical,hemorheologic and traditional Chinese medicine syndrome score were observed in the two groups before and after treatment,the clinical efficacy of the two groups was compared,and the occurrence of adverse reactions in the two groups was observed.Results:The total clinical efficacy of the study group was significantly higher than that of the control group,and the difference was statistically significant(93.0％vs 85.0％,P＜0.05).After treatment,the indexes of cerebral hemodynamics and hemorheology in both groups were significantly improved compared with those before treatment,and the indexes of cerebral hemodynamics and hemorheology in the study group were significantly better than those in the control group(P＜0.05).After treatment,the scores of traditional Chinese medicine syndrome in both groups were less than that before treatment,and those in the study group was significantly less than those in the control group,with statistical significance(P＜0.05).There were no significant adverse reactions during the study period.Conclusion:Longshengzhi capsules for treating vertigo of Qi deficiency and blood stasis could improve the clinical symptoms,which might be related to the improvement of cerebral hemodynamics and hemorheology.

vertigoQi deficiency and blood stasisLongshengzhi capsulescerebral hemodynamicshemorheologytraditional Chinese medicine syndrome

姜超、贾明华、刘文、李晓静、徐中菊

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西安医学院第二附属医院(西安 710038)

延安大学咸阳医院(陕西咸阳 712000)

上海市光华中西医结合医院(上海 200052)

眩晕 气虚血瘀型 龙生蛭胶囊 脑血流动力学 血液流变学 中医证候

2022年"步长杯"脑心同治科研基金重大科研项目陕西省科技厅重点研发计划项目上海市长宁区卫健委,徐中菊名中医工作室建设项目上海市长宁区博士创新基地建设项目西安市科技支撑项目西安医学院第二附属医院国科金面上培育项目陕西省脑疾病防治重点实验室开放基金项目

NXTZ202211012020SF-344CNMZY-2021008RCJD2021B0422YXYJ009623KY010120NBZD02

2024

10.12102/j.issn.1672-1349.2024.15.028

中西医结合心脑血管病杂志
中国中西医结合学会　山西医科大学第一医院

中西医结合心脑血管病杂志

CSTPCD
影响因子：1.463
ISSN：1672-1349
年,卷(期)：2024.22(15)