Meta-analysis of Efficacy and Safety of Banxia Baizhu Tianma Decoction in the Treatment of H-type Hypertension
Objective:To systematically review the efficacy and safety of Banxia Baizhu Tianma Decoction in the treatment of H-type hypertension.Methods:Chinese and English databases such as CNKI,WanFang Data,VIP,China Biomedical Literature Database,PubMed,and EMbase were searched for randomized controlled trials(RCTs)comparing Banxia Baizhu Tianma Decoction(test group)with conventional western medicine(control group)for the treatment of H-type hypertension from inception until February 25,2022.Literatures was screened and data were extracted.At the same time,the quality of the included literature was evaluated using the bias risk assessment tool recommended in the Cochrane Manual of Systematic Reviewers 5.1.0.The RevMan 5.4 software was used for Meta-analysis.Results:A total of 17 RCTs with 1 327 patients were included.The results of Meta analysis showed that the homocysteine(Hcy)level(SMD=-2.77,95%CI-3.52--2.02,P<0.000 01),systolic blood pressure(MD=-10.42,95%CI-12.91--7.93,P<0.000 01),diastolic blood pressure(MD=-8.92,95%CI-10.38--7.46,P<0.000 01),C-reactive protein(CRP)level(MD=-10.73,95%CI-11.34--10.11,P<0.000 01),matrix metalloproteinase 9(MMP-9)level(MD=-16.17,95%CI-17.04--15.30,P<0.000 01),tumor necrosis factor-α(TNF-α)level(MD=-30.69,95%CI-31.90--29.47,P<0.000 01),and the incidence of adverse reactions(RR=0.38,95%CI 0.15-0.92,P=0.03)in experiment group were significantly lower than those in control group,and the folic acid level(MD=7.11,95%CI 6.61-7.61,P<0.000 01),vitamin B12 level(SMD=2.44,95%CI 2.11-2.77,P<0.000 01),total effective rate of clinical efficacy(RR=1.21,95%CI 1.15-1.28,P<0.000 01)were significantly higher than those in control group.Conclusion:Available evidence suggests that modification of Banxia Baizhu Tianma Decoction may improve the clinical efficacy in the treatment of H-type hypertension,effectively reduce the level of Hcy,with fewer adverse reactions and higher safety,but the clinical efficacy conclusion still needs to be further verified by expanding the sample size.
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