Efficacy and Safety of Sodium TanshinoneⅡA Sulfonate for the Treatment of Coronary Heart Disease Angina Pectoris:a Meta-analysis
Objective:To evaluate the efficacy and safety of sodium tanshinone ⅡA sulfonate for the treatment of coronary heart disease angina pectoris.Methods:CNKI,VIP,Wanfang Database,CBM,PubMed,the Cochrane Library,and EMbase databases were searched to collect the studies of the correlation between sodium tanshinone ⅡA sulfonate and angina,the deadline was September 30,2022.Two participants independently screened the literature,extracted information,and assessed the risk of bias of the included studies.RevMan 5.3 software was used for Meta-analysis.Results:Twenty studies involving 2 975 patients were included.The results of Meta-analysis showed that the clinical efficacy of sodium tanshinone ⅡA sulfonate combined with conventional western medicine for coronary heart disease angina pectoris(OR=3.32,95%CI 2.66-4.15,P<0.000 01),angina pectoris attack(MD=-1.38,95%CI-1.83--0.92,P<0.000 01),duration of angina(MD=-6.27,95%CI-8.06--4.48,P<0.000 01),electrocardiograph efficacy(OR=2.54,95%CI 1.92-3.36,P<0.000 01),total cholesterol(MD=-1.20,95%CI-1.68--0.71,P<0.000 01),triacylglycerol(MD=-0.50,95%CI-0.74--0.26,P<0.000 01),high density lipoprotein cholesterol(MD=0.17,95%CI 0.01-0.33,P<0.000 01),low density lipoprotein cholesterin(MD=-0.54,95%CI-0.84--0.24,P<0.000 01)were better than those of conventional western medicine alone.Conclusion:The current limited evidence shows that sodium tanshinone ⅡA sulfonate combined with conventional western medicine for the treatment of angina pectoris is superior to conventional treatment.However,more studies are needed to provide more reliable evidence of its safety.
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