Clinical Efficacy of Enhanced External Counterpulsation Combined with Stable Patch Therapy for the Treatment of Refractory Angina
Objective:To exploring the clinical efficacy of enhanced external counterpulsation(EECP)combined with stable patch therapy for the treatment of refractory angina.Methods:Eighty patients with refractory angina were divided into experimental group and control group according to random number table method,with 40 cases in each group.The control group was treated with conventional drugs,and the experimental group received the EECP and stable patch therapy on the basis of conventional drugs.The number of angina attacks,degree of angina pain,dosage of nitroglycerin tablets,quality of life,anxiety status,and endothelial microparticle levels between the two groups were observed before and after treatment.Results:After treatment,the number of angina attacks,visual analogue scale(VAS)score and nitroglycerin consumption in 2 groups decreased,and the experimental group were lower than that of the control group,the differences were statistically significant(P<0.05).After treatment,the score of health related Quality of Life Scale(SF-12)in experimental group was higher than that before treatment,and higher than that in control group,with statistical significance(P<0.05).After treatment,the score of Hamilton Anxiety Scale(HAMA)in the experimental group was lower than that before treatment,and lower than that in the control group,with statistical significance(P<0.05).After treatment,the level of endothelial microparticles in experimental group was lower than that before treatment,and lower than that in control group,with statistical significance(P<0.05).Conclusion:Enhanced external counterpulsation combined with stable patch could effectively relieve the clinical symptoms and improve the quality of life of patients with refractory angina pectoris.The mechanism may be related to improving vascular endothelial function,increasing myocardial perfusion and coronary blood flow reserve,and thus alleviating the attack of angina pectoris.
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