Effect of Shenfu Injection Combined with Conventional Western Medicine on Brain Injury in Patients with Traumatic Hemorrhagic Shock
Objective:To explore the effect of Shenfu injection combined with conventional western medicine on brain injury in patients with traumatic hemorrhagic shock.Methods:A total of 115 patients with traumatic hemorrhagic shock were divided into group A(50 cases)and group B(65 cases)according to different treatment methods.Group A received conventional western medicine for anti-shock treatment,group B received Shenfu injection on the basis of group A.The scores of Glasgow Coma Scale(GCS),shock recovery(shock index,lactate level,lactate clearance rate),cerebral perfusion(cerebral perfusion pressure,cerebral blood flow),thrombin time(TT),prothrombin time(PT),activated partial thrombin time(APTT),fibrinogen(FIB),international standard normalized ratio(INR),interleukin-6(IL-6),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α),and complications(disseminated intravascular coagulation,multiple organ dysfunction syndrome,acute respiratory distress syndrome,pulmonary infection)of the two groups were compared.Results:After 24 h of treatment,GCS score of both groups increased,and GCS score of group B was higher than that of group A(P<0.05).After 24 h of treatment,the shock index and lactic acid level of both groups decreased,and the shock index and lactic acid level of group B were lower than those of group A(P<0.05).After treatment,the lactic acid clearance rate of group B was higher than that of group A(P<0.05).After 24 h of treatment,cerebral perfusion pressure and cerebral blood flow increased in both groups,and cerebral perfusion pressure and cerebral blood flow in group B were higher than those in group A(P<0.05).After 24 h of treatment,TT,PT,APTT,FIB,and INR decreased in both groups,and TT,PT,APTT,FIB,and INR in group B were less than those in group A(P<0.05).After 24 h of treatment,IL-6,IL-10 and TNF-αdecreased in two groups,and IL-6,IL-10 and TNF-αin group B were lower than those in group A(P<0.05).The incidence of complications in group B was lower than that in group A(P<0.05).Conclusion:Shenfu injection combined with conventional western medicine showed better effect for the treatment of patients with traumatic hemorrhagic shock,which could effectively improve the coma and shock state of patients,increase the perfusion of brain tissue,improve the coagulation function indicators,reduce the level of inflammatory factors and reduce complications.
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