Relationship between Serum KAL,ENOX1 and Coronary Artery Plaque Stability,Prognosis in Patients with Coronary Heart Disease
Objective:To analyze the relationship between serum kallistatin(KAL),Ecto-NOX disulfide mercaptan exchanger-1(ENOX1)levels and coronary artery plaque stability and prognosis in patients with coronary heart disease.Methods:A total of 103 patients with coronary heart disease were divided into unstable group(47 cases)and stable group(56 cases)according to coronary artery plaque stability.According to the occurrence of major adverse cardiovascular events after 6 months,103 patients were divided into poor prognosis group(34 cases)and good prognosis group(69 cases).Another 50 healthy subjects in the same period were selected(control group).Serum KAL and ENOX1 levels were detected by enzyme-linked immunosorbent assay.Spearman method was used to analyze the correlation between serum KAL and ENOX1 levels in patients with coronary heart disease.Multivariate Logistic regression was used to analyze the relationship between serum KAL,ENOX1 levels and coronary plaque instability,prognosis in patients with coronary heart disease.The value of serum KAL and ENOX1 levels was analyzed by receiver operating characteristic(ROC)curve.Results:Serum KAL level in the CHD group was lower than that in the control group,and ENOX1 level was higher than that in the control group(P＜0.001).Serum KAL level in the unstable group was lower than that in the stable group,and ENOX1 level was higher than that in the stable group(P＜0.001).Serum KAL level in the poor prognosis group was lower than that in the better prognosis group,and ENOX1 level was higher than that in the better prognosis group(P＜0.001).Spearman correlation analysis showed that serum KAL was negatively correlated with ENOX1 level in CHD patients(r=-0.780,P＜0.001).Multivariate Logistic regression analysis showed that the increased KAL was an independent protective factor for coronary plaque instability and poor prognosis in patients with coronary heart disease,and the increased ENOX1 was an independent risk factor.ROC curve analysis showed that the combined predictive value of serum KAL and ENOX1 levels of coronary artery plaque instability and poor prognosis in patients with coronary heart disease had a higher area under the ROC curve than predictive value of the single index.Conclusion:The decreased KAL level and the increased ENOX1 level in patients with coronary heart disease were associated with coronary plaque instability and poor prognosis,and the combination of KAL and ENOX1 showed a high value in the evaluation of coronary artery plaque stability and prognosis in patients with coronary heart disease.
万方数据
维普
