Relationship between Blood Pressure Variability,Pulse Pressure Index and Cognitive Function in Patients with H-type Hypertension Complicated with ACI
Objective:To analyze the relationship between blood pressure variability(HPV),pulse pressure index(PPI)and cognitive function in patients with H-type hypertension complicated with acute cerebral infarction(ACI).Methods:One hundred and twenty patients with H-type hypertension were selected.According to whether the patients were comorbid with ACI or not,48 patients with comorbid ACI were selected as the comorbid group,72 patients without comorbid ACI were selected as the non-comorbid group,and 60 healthy check-ups in our medical check-up centre during the same period were selected as the control group.The cognitive function of the patients was assessed by the Montreal Cognitive Assessment(MoCA).Serum homocysteine(Hcy),24 h systolic blood pressure variation coefficient(24 hSCV),24 h diastolic blood pressure variation coefficient(24 hDCV),PPI and MoCA scores were compared among the 3 groups.The serum Hcy,24 hSCV,24 hDCV and PPI in ACI patients with different cognitive dysfunction were compared.Pearson method was used to analyze the correlation between serum Hcy,24 hSCV,24 hDCV,PPI and MoCA score.Receiver operating characteristic(ROC)curve were plotted,the area under the ROC curve(AUC)was calculated,and the predictive value of serum Hcy,24 hSCV,24 hDCV,PPI,and MoCA scores for cognitive dysfunction was analyzed.Results:Serum Hcy,24 hSCV,24 hDCV and PPI in the comorbid group were more than those in the non-comorbid group and control group(P＜0.05).Serum Hcy,24 hSCV,24 hDCV and PPI in the non-combined group were more than those in the control group(P＜0.05).MoCA different dimension scores and total scores in the increased group were less than those in the non-combined group and the control group(P＜0.05).The orientation,abstract thinking,attention and total score of the non-combined group were lower than those of the control group(P＜0.05).Serum Hcy,24 hSCV,24 hDCV and PPI in the cognitive dysfunction group were more than those in the non-cognitive dysfunction group,and the difference was statistically significant(P＜0.05).Serum Hcy,24 hSCV,24 hDCV and PPI were positively correlated with MoCA score(P＜0.05).The results of ROC curve showed that the AUC of combined detection with serum Hcy,24 hSCV,24 hDCV,PPI,and MoCA score for predicting cognitive dysfunction was 0.792,which was higher than the predictive value of the single index(P＜0.05).Conclusion:Higher serum Hcy,24 hSCV,24 hDCV,and PPI in patients with H-type hypertension complicated with ACI were related to cognitive function,and combined detection of of serum Hcy,24 hSCV,24 hDCV,PPI,and MoCA scores might improve the predictive value of cognitive dysfunction.
acute cerebral infarctionH-type hypertensionblood pressure variabilitypulse pressure indexcognitive function
万方数据
维普
