Compatibility Application of Bupleurum for Coronary Heart Disease with Depression or Anxiety Based on Data Mining
Objective:To explore the compatibility application of bupleurum in the treatment of coronary heart disease with depression or anxiety based on data mining.Methods:The traditional Chinese medicine prescriptions for the treatment of coronary heart disease with depression or anxiety containing bupleurum were collected from CNKI,Wanfang,and VIP databases from the establishment of the database to January 2023.The Excel prescription database was established to calculate the frequency,efficacy classification,and meridian tropism of traditional Chinese medicine.SPSS Modeler 18.0 and SPSS Statistics 27.0 software were used to analyze the association rules and cluster analysis of high-frequency traditional Chinese medicine,and Cytoscape 3.7.2 software was used to construct the network view.Results:A total of 91 prescriptions were included.In addition to bupleurum,109 kinds of traditional Chinese medicine and 18 kinds of drugs were involved.The frequency of medication was 993 times.The top 5 Chinese medicines were licorice,white peony root,salvia miltiorrhiza,turmeric,and chuanxiong.The efficacy classification was mainly based on tonifying deficiency,activating blood circulation to dissipate blood stasis,regulating qi,tranquilizing,clearing heat,and resolving phlegm.The nature of drugs was mainly warm,cold,and flat,and the taste of drugs was mainly bitter,sweet,and pungent,which mainly belongs to the liver,heart,and spleen meridians.The core drug pairs were licorice-bupleurum,white peony-bupleurum,salvia miltiorrhiza-bupleurum,turmeric-bupleurum,and chuanxiong-bupleurum.Cluster analysis obtained 6 groups of multi-flavor core drug groups.Conclusion:Bupleurum is popular for evacuation of liver meridian stagnation,which shows the function of promoting qi and relieving depression,and smoothing qi movement.ln clinical treatment,bupleurum is often combined with traditional Chinese medicines for tonifying deficiency,activating blood,regulating qi,tranquilizing mind,clearing heat,and resolving phlegm,and it is often combined with licorice,white peony root,Salvia miltiorrhiza,turmeric,and Chuanxiong.The clinical application of prescriptions containing bupleurum reflects the core pathogenesis and basic therapeutic principles of coronary heart disease with depression or anxiety.
万方数据
维普
