Objective:Clinical randomized controlled trials(RCTs)of Chinese medicinal preparations for stable angina pectoris were collected,summarized,analyzed and evaluated,with the aim of providing reference evidence for more clinical studies and promoting the progress and development of clinical research.Methods:The databases of Chinese National Knowledge Infrastructure(CNKI),WanFang Medical Network(WanFang),VIP,China Biomedical Literature Service(CBM),PubMed,EMbase,and the Cochrane Library were searched.The search period was from the establishment of the database to May 1,2022.Clinical RCTs of Chinese medicinal preparations for the treatment of stable angina were included,and their year of publication,sample size,duration of treatment,intervention/control measures,outcome indicators,and methodological quality were analyzed and evaluated.Results:A total of 493 RCTs were included,involving 104 Chinese medicinal preparations,59 RCTs with a sample size>150.A total of 31 interventions/controls,with Chinese medicinal preparations+conventional treatment vs conventional treatment being the most frequent(187).A total of 467 RCTs reported specific duration of treatment,with 14-28 d being the predominant.Evaluation of outcome indicators was dominated by physical and chemical tests,and quantitative indicators were dominated by blood lipids,count indicators were dominated by electrocardiographic efficacy(efficiency).In the methodology section,a significant number of RCTs fail to provide clear descriptions or any details regarding the processes of allocation concealment and blinding implementation,resulting in a lack of standardization in their execution.Ethical approval,informed consent,and trial registration were not reported in advance.The published RCTs of Chinese medicinal preparations for stable angina pectoris showed slight deficiencies in design and implementation,which had an impact on the trial results.Therefore,the standardization and rigor of trial design and implementation need to be further strengthened to improve the reliability of clinical trials.
stable anginaChinese medicinal preparationrandomized controlled trialevidence-based medicine
维普
万方数据
