Objective:To investigate the effect of Xinkeshu on cardiac dysfunction in patients with coronary heart disease.Methods:Thirty patients with cardiac insufficiency diagnosed as coronary heart disease were randomly divided into control group(15 cases)and observation group(15 cases)according to the complete random number method.The patients in control group received conventional drug treatment combined with placebo,while the patients in observation group received conventional drug treatment combined with Xinkeshu tablets for 8 weeks.The cardiac function of the two groups before,during,and after treatment was compared:serum brain natriuretic peptide(BNP),left ventricular ejection fraction(LVEF),and 6-minute walk test(6MWT).The Minnesota Living with Heart Failure Questionnaire(MLHFQ)were used to evaluate the quality of life,and the safety was observed.Results:Before treatment,there was no significant difference in general information,6MWT,MLJFQ score,BNP level,and LVEF between the two groups of patients(P>0.05).During 4 weeks of treatment,the 6MWT and MLJFQ scores of both groups were improved compared to those before treatment,these data were no significant difference in the control group(P>0.05),while,these data were significant difference in the observation group(P<0.05).The 6MWT score of the observation group was better than that of the control group(P<0.05).After 8 weeks of treatment,the 6MWT and MLJFQ scores of both groups were improved compared to that before treatment(P<0.05),and the 6MWT and MLJFQ scores of the observation group were better than those of the control group(P<0.05).After 8 weeks of treatment,there was no significant decrease in BNP in the control group compared to before treatment(P>0.05).However,BNP in the observation group decreased significantly compared to those before treatment(P<0.05)and was lower than that in the control group(P<0.05).After 8 weeks of treatment,there was no significant improvement in LVEF in two groups compared to that before treatment(P>0.05),and there was no statistically significant difference in two groups(P>0.05).Compared to the control group,the observation group exhibited no significant alterations in blood routine or liver and kidney function indicators after 8 weeks of treatment.There was no statistically significant difference in adverse reactions between the two groups(P>0.05).Conclusion:Compared to conventional drug therapy,the combination of conventional drug therapy and Xinkeshu tablets can more effectively improve the cardiac function of patients with coronary heart disease and heart failure,the main pathogenesis is blood stasis in the heart,in a shorter period of time.This treatment could improves quality of life and with better safety.
coronary heart diseasecardiac dysfunctionXinkeshuserum brain natriuretic peptideleft ventricular ejection fraction6-minute walk test
维普
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