Objective:To observe the prognostic value of left ventricular global longitudinal strain(LVGLS) and left ventricular ejection fraction(LVEF) in patients with sepsis-induced cardiomyopathy(SIC).Methods:The clinical data of 108 patients with SIC were retrospectively selected and divided into survival group and death group according to the 28 d survival.The clinical data,left ventricular strain parameters and cardiac function indicators were compared between the two groups.Multiple Logistic regression was used to analyze the factors affecting prognosis of SIC patients.Receiver operating characteristic ( ROC) curve was used to analyze the prognostic value of LVGLS and LVEF in SIC patients.Results:Among the 108 patients with SIC,35 patients died(death group) and 73 patients survived(survival group) during 28 d of follow up.The levels of Acute Physiology and Chronic Health Status Score Ⅱ(APACHEⅡ),Sequential Organ Failure Score(SOFA),troponin I(cTnI) and blood lactic acid(Lac) in death group were higher than those in survival group within 24 h after admission(P<0.05),LVGLS absolute value,GRS absolute value and LVEF were lower than those of the survival group(P<0.05).Multiple Logistic regression analysis showed that APACHEⅡ score,cTnI,Lac,LVGLS,and LVEF were independent prognostic factors of SIC patients(P<0.05).ROC curve results showed that the best cutoff value for LVGLS to predict the prognosis of SIC patients was-12.33％,the best cutoff value for LVEF were 29.43％.The area under the curve(AUC) and sensitivity of LVGLS combined with LVEF to predict the prognosis of SIC patients were higher than those predicted by single index(P<0.05).Conclusion:APACHEⅡ score,cTnI,Lac,LVGLS,and LVEF levels at admission are independent prognostic factors of SIC patients.LVGLS combined with LVEF shows a high prognostic value for SIC patients,and can be used as the main clinical index for prognosis evaluation.
sepsis-induced cardiomyopathyleft ventricular global longitudinal strainleft ventricular ejection fractionprognosispredictive value
维普
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