Relationship Between Dried Fruit Intake and Type 2 Diabetes:a Mendelian Randomization Study
Objective:Two-sample Mendelian randomization(MR) analysis was used to investigate the relationship between dried fruit intake(DFI) and type 2 diabetes mellitus(T2DM).Methods:Genome-wide association analysis(GWAS)data for DFI(421764 cases)were obtained from UK Biobank as exposure for this MR study,and GWAS data(898130 cases) associated with T2DM were obtained from the DIAGRAM consortium database as a discovery dataset for outcomes.To verify the reliability of the results,the T2DM GWAS data (304769 cases)of another cohort population was obtained in the FINNGEN database as the replication dataset.All the above data were from European populations.The inverse variance-weighted method(IVW),MR Egger method,weighted median method(WME),simple mode method(SM),and weighted majority method(WM)were used for MR analysis,and the results were evaluated according to the effect index ratio(OR)and 95％ CI.Results:MR analysis with IVW as the main analysis method showed that the increase of DFI could reduce the risk of T2DM(IVW OR=0.434,95％ CI 0.312-0.602),and the direction of effect evaluated by the other four methods were consistent with that of IVW.The results of replication dataset analysis reaffirmed the above findings,and no pleiotropy was found in any of the analyses.Conclusion:There is relationship between higher DFI and a reduced risk of T2DM.
type 2 diabetes mellitusdried fruit intakeMendelian randomization
万方数据
维普
