The metabolites of a marine streptomyces sp. actinomycete( No. 195-02) were studied and eight compounds were isolated from the fermentation liquid, structures were elucidated by spectroscopy methods as p-hydroxy-benzonitrile( 1), 2-methyl-furan-3-carboxylic acid(2), furan-2-carboxylie acid(3), cyclo(Phe-Phe) (4) ,cyclo( Leu-Ileu) (5) ,nicotinic acid (6) ,2-( 1H-indol-3-yl) acetic acid(7) and bis(2-ethylhexyl) phthalate(8). The compounds 1,3 and 8 were firstly isolated from Streptomyces sp. , compounds 4-7 were firstly found from marine actinomycetes. Coumpouds 4 and 5 evidently inhibited the growth of cancer cell lines hepG2 and hep2 at the concentration of 50μg/ml.
国家科技期刊平台
NSTL
万方数据
维普
