Preparation and Characterization of Pharmaceutical Properties of Tanshinone ⅡA Microspheres
Objective:To optimize the polymer material and process condition for preparation of tanshinone Ⅱ A microspheres by orthogonal design.Methods:The microspheres were prepared by emulsion solvent evaporation method.The optimum polymer material and preparation process were clarified by the comprehensive weighted score which was evaluated with the drug loading,encapsulation efficiency,and yield.The quality characterization of the tanshinone Ⅱ A microspheres were assayed by SEM,laser particle size analyzer,TG-DSC,and XRD.Results:The drug loading and encapsulation rate of microspheres prepared by PLLA was significantly higher than that of other polymer material.The surface of TA-PLLA-MS was round with porous structure,average particle size was (96.95 ± 1.7) μm,the drug loading was(30.43 ± 0.04)％,the entrapment efficiency was (82.72 ± 1.51)％,and the yield was (94.10 ± 1.60)％.The drug crystal form was still in the microspheres from the results of TG-DSC and XRD.Conclusion:The PLLA tanshinone Ⅱ A microspheres were prepared by emulsion solvent evaporation method which was simple,stable,and enough loaded drug.
国家科技期刊平台
NSTL
万方数据
