杏苏二陈汤联合止咳化痰贴治疗小儿肺炎恢复期痰湿阻肺证42例临床观察

Clinical observation on Xingsu Erchen Tang(杏苏二陈汤)combined Zhike Huatan Tie(止咳化痰贴)in treating children with pneumonia in convalescence stage of phlegm-dampness stagnation in the lung syndrome

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中文摘要：目的观察杏苏二陈汤联合止咳化痰贴治疗小儿肺炎恢复期痰湿阻肺证的临床疗效.方法选取2019年10月至2020年12月在南京中医药大学附属南京中医院儿科住院部收治的肺炎恢复期痰湿阻肺证患儿8 2例,按照随机数字表法分为治疗组42例和对照组40例.2组患儿均给予止咳化痰贴,敷于天突、膻中、肺俞,每日贴4～8 h.对照组给予氨溴特罗口服溶液口服,治疗组给予中药杏苏二陈汤口服.2组均治疗5 d后统计临床疗效、中医证候积分、症状和体征改善情况及安全性.结果治疗组总有效率为88.10％(37/42),对照组为62.50％(25/40),2组比较,差异有统计学意义(P＜0.05).治疗前2组中医证候总积分比较,差异无统计学意义(P＞0.05),具有可比性;治疗后2组中医证候总积分均显著下降,与同组治疗前比较,差异有统计学意义(P＜0.05),且治疗组下降更显著(P＜0.05).治疗组的主症(咳嗽频率、咳嗽消失时间)和次症(腹胀、食欲不振、大便不调消失时间)改善情况均优于对照组,经统计学分析,差异有统计学意义(P＜0.05).2组治疗后行血常规、尿常规、大便常规检查,均无异常;2组患儿谷丙转氨酶(ALT)、谷草转氨酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶同工酶(CK-MB)、肌酐(Scr)和尿素(BUN)均在正常范围内.结论杏苏二陈汤联合止咳化痰贴治疗小儿肺炎恢复期痰湿阻肺证疗效显著,可明显减少患儿咳嗽发作频率和持续时间,改善腹胀、食欲不振、大便不调等症状,安全性较高,值得临床推广应用.

外文摘要：Objective To observe the clinical efficacy of Xingsu Erchen Tang(杏苏二陈汤)combined Zhike Huatan Tie(止咳化痰贴)treating children with pneumonia in convalescence stage of phlegm-dampness stagnation in the lung syndrome.Methods 82 children with pneumonia in convalescence stage of phlegm-dampness stagnation in the lung syndrome were divided into 2 groups.Children assigned to the control group were given Ambroxol hydro-chloride and Clenbuterol hydrochloride oral solution,as well as Zhike Huatan Tie,and children assigned to the treat-ment group were given Xingsu Erchen Tang for 5 days.Results The total effective rate was 88.10％(37/42)in the treatment group and 62.50％(25/40)in the control group.The treatment group was better than the control group(P＜0.05).The scores of the two groups after treatment were lower than those before treatment(P＜0.05),and the scores of the treatment group after treatment were lower than those of the control group after treatment(P＜0.05).The coughing frequency in the treatment group was lower than that in the control group(P＜0.05),the disap-pearance time of rales was shorter than that in the control group(P＜0.05),and the recurrence rate was lower than that in the control group(P＜0.05).The time for improving symptoms such as sweating,loss of appetite and abnor-mal stools in the treatment group was shorter than that in the control group(P＜0.05).The routine blood tests,urine tests and stool tests in two groups were normal,and the level of AST,LDH,CK-MB,Scr and BUN were normal.Conclusion Xingsu Erchen Tang combined Zhike Huatan Tie is effective in treating phlegm-dampness stagnation in the lung syndrome during the convalescence stage of pediatric pneumonia,which can significantly reduce the fre-quency and duration of coughing episodes and improve the symptoms of abdominal distension,nausea,and irregular bowel movements,with a high degree of safety,which is worthy of clinical promotion and application.

外文关键词：

childrenconvalescence stage of pediatric pneumoniaphlegm-dampnessstagnation in the lung syn-dromeXingsu Erchen Tang(杏苏二陈汤)Zhike Huatan Tie(止咳化痰贴)clinical observation

作者：

王爱华、杜晶花、王婉妮

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作者单位：

南京中医药大学附属南京中医院儿科,江苏南京 210022

关键词：

小儿肺炎恢复期痰湿阻肺证杏苏二陈汤止咳化痰贴临床观察

基金：

国家自然科学基金青年项目十四五南京市中医药青年人才培养计划项目南京市张骠名中医工作室建设项目

项目编号：

82205183ZYQ20039宁卫中医[2017]8号

出版年：

2024

DOI：

10.16840/j.issn1673-4297.2024.01.11

中医儿科杂志

甘肃中医学院，中华中医药学会

中医儿科杂志

影响因子：0.82

ISSN：1673-4297

年,卷(期)：2024.20(1)

参考文献量6