Clinical observation on 56 cases of acute bronchopneumonia with phlegm heat obstruction in the lungs treated with Xiao'er Feire Kechuan Granules(小儿肺热咳喘颗粒)as an adjuvant therapy
Objective To observe the clinical efficacy of Xiao'er Feire Kechuan Granules(小儿肺热咳喘颗粒)as an adjuvant therapy for acute bronchopneumonia with phlegm heat obstruction in the lungs in children,and its impact on the inflammatory response and immune function of the children's body.Methods A total of 112 ped-iatric patients with acute bronchopneumonia with phlegm heat obstruction in the lungs admitted to the Department of Pediatrics,the First Affiliated Hospital of Ningbo University from June 2020 to June 2022 were selected.They were randomly divided into a treatment group and a control group using a random number table method,with 56 cases in each group.Both groups were given routine symptomatic treatments such as oxygen inhalation,cooling,cough relie-ving and phlegm resolving,and anti infection.The control group was given nebulized inhalation on the basis of the symptomatic treatment mentioned above.The treatment group was given oral administration of Xiao'er Feire Kech-uan Granules in combination with the control group's treatment method.The two groups were treated for 7 days per course,and the clinical efficacy was calculated after one course of treatment.Results The total effective rate of the treatment group was 96.43％(54/56),significantly higher than the control group's 85.71％(47/56).The differ-ence between the two groups was statistically significant(P＜0.05).The disappearance time of cough and sputum,lung rales,and normal body temperature in the treatment group were all earlier than those in the control group.Com-parison of the levels of inflammatory factors serum interleukin-8(IL-8),C-reactive protein(CRP)and tumour nec-rosis factor-α(TNF-α)in the 2 groups before treatment,the difference was not statistically significant(P＞0.05)and was comparable;after treatment,the levels of serum IL-8,CRP and TNF-α in the 2 groups decreased signifi-cantly,and the difference was statistically significant when compared with the same group before treatment(P＜0.05),and the decrease was more significant in the treatment group(P＜0.05).Comparison of serum immunoglobu-lin A(IgA),immunoglobulin G(IgG),and immunoglobulin M(IgM)levels between the two groups before treat-ment showed no statistically significant difference(P＞0.05),and the differences were comparable;serum levels of IgA,IgG,and IgM in the two groups after treatment were significantly increased,and the differences were statistically significant when compared with those of the same group before treatment(P＜0.05),and the increase in the treat-ment group was more significant,the difference was statistically significant when compared with the same group be-fore treatment(P＜0.05),and the increase was moresignificant in the treatment group(P＜0.05).Conclusion Xi-aoer Feire Kechuan Granule has a significant effect on children with acute bronchopneumonia with phlegm heat ob-struction in the lungs as an adjuvant therapy,which can improve the symptoms of children,reduce the inflammatory reaction of the body,and improve the immunity of children.It is worthy of reference for clinical application.
childrenacute bronchopneumoniaphlegm heat obstruction in the lungs syndromeXiao'er Feire Kechuan Granules(小儿肺热咳喘颗粒)inflammatory factorsimmune functionclinical observation
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