Study on the mechanism of Xiaoer Zhixiao Pingchuan Granule(小儿止哮平喘颗粒)in the treatment of bronchial asthma based on network pharmacology
Objective To explore the mechanism of Xiaoer Zhixiao Pingchuan Granule(小儿止哮平喘颗粒)in the treatment of bronchial asthma by means of network pharmacology.Methods The active components and ac-tion targets of Xiaoer Zhixiao Pingchuan Granule were screened by TCMSP and SymMap database,and the disease-related targets of bronchial asthma were screened by NCBIGene,GeneCards,TTD,KEGG,MalaCards,PharmGKB,OMIM and other databases,and the intersection targets(common targets)of active components and disease-related targets were obtained,that is,the potential targets of Xiaoer Zhixiao Pingchuan Granule in the treatment of bronchial asthma.The"traditional Chinese medicine-chemical composition target-disease"network was constructed by Cyto-scape3.2.1 software,and the above common targets were imported into String database to obtain data.The"compo-nent target-disease target"network was constructed in Cytoscape3.2.1 software,and GO and KEGG pathway enrich-ment analysis was carried out by using Metascape database.Results A total of 289 active components and 470 po-tential targets were screened,and the core active components such as ethycholest-4-en-3-one,(+)-Leucocyanidin,miltionone I,delphinin,(E)-(4-methylbenzylidene-(4-phenyltriazol-1-yl)amine,oleic acid),AKT1,TP53,CTNNβ1,JUN,HRAS,GRB2 and PPARG were obtained.AGE-RAGE signal pathway,calcium signal pathway,cAMP signal pathway,TNF signal pathway,PI3K-Akt signal pathway and other key signal pathways were screened.Conclusion Xiaoer Zhixiao Pingchuan Granule can treat bronchial asthma by regulating multiple pathways with multi-components and multi-targets,which lays a foundation for the study of its molecular mechanism.
Xiaoer Zhixiao Pingchuan Granule(小儿止哮平喘颗粒)bronchial asthmanetwork pharmacolo-gymechanism of action
NETL
NSTL
万方数据
