Objective To explore the mechanism of Xiaoer Zhixiao Pingchuan Granule(小儿止哮平喘颗粒)in the treatment of bronchial asthma by means of network pharmacology.Methods The active components and ac-tion targets of Xiaoer Zhixiao Pingchuan Granule were screened by TCMSP and SymMap database,and the disease-related targets of bronchial asthma were screened by NCBIGene,GeneCards,TTD,KEGG,MalaCards,PharmGKB,OMIM and other databases,and the intersection targets(common targets)of active components and disease-related targets were obtained,that is,the potential targets of Xiaoer Zhixiao Pingchuan Granule in the treatment of bronchial asthma.The"traditional Chinese medicine-chemical composition target-disease"network was constructed by Cyto-scape3.2.1 software,and the above common targets were imported into String database to obtain data.The"compo-nent target-disease target"network was constructed in Cytoscape3.2.1 software,and GO and KEGG pathway enrich-ment analysis was carried out by using Metascape database.Results A total of 289 active components and 470 po-tential targets were screened,and the core active components such as ethycholest-4-en-3-one,(+)-Leucocyanidin,miltionone I,delphinin,(E)-(4-methylbenzylidene-(4-phenyltriazol-1-yl)amine,oleic acid),AKT1,TP53,CTNNβ1,JUN,HRAS,GRB2 and PPARG were obtained.AGE-RAGE signal pathway,calcium signal pathway,cAMP signal pathway,TNF signal pathway,PI3K-Akt signal pathway and other key signal pathways were screened.Conclusion Xiaoer Zhixiao Pingchuan Granule can treat bronchial asthma by regulating multiple pathways with multi-components and multi-targets,which lays a foundation for the study of its molecular mechanism.
Xiaoer Zhixiao Pingchuan Granule(小儿止哮平喘颗粒)bronchial asthmanetwork pharmacolo-gymechanism of action
NETL
NSTL
万方数据
