Clinical observation on 50 cases of lung-spleen qi deficiency syndrome in children of primary nephrotic syndrome adjuvantly treated with modified Fangji Huangqi Tang(防己黄芪汤)
Objective To observe the clinical efficacy of modified Fangji Huangqi Tang(防己黄芪汤)com-bined with Western medicine in the treatment of children with primary nephrotic syndrome(PNS)of lung-spleen qi deficiency syndrome.Methods From January 2019 to January 2021,100 children of PNS with lung-qi deficiency syndrome were selected and divided into a treatment group and a control group by random number table method,with 50 cases in each group.The control group was given oral prednisone acetate tablet and subcutaneous injection of low molecular weight heparin sodium,and the treatment group was combined with modified Fangji Huangqi Tang based on the treatment method of the control group.After 4 weeks of treatment,the clinical efficacy of both groups was statistically analyzed.The plasma albumin(ALB),total cholesterol(TC),triglycerides(TG),platelet count(PLT),plasma fibrinogen(FIB),D-dimer,activated partial thromboplastin time(APTT),CD4+,CD8+,CD4/CD8 ratio of T lymphocyte immune function,and 24-hour urine protein quantification were compared between the two groups before and after treatment.Results The total effective rate of the treatment group was 92.0％(46/50),sig-nificantly higher than the control group's 78.0％(39/50),and the difference between the two groups was statisti-cally significant(P＜0.05).There was no statistically significant difference(P＞0.05)in the quantitative values of ALB,TC,TG,and 24-hour urine protein between the two groups before treatment,indicating comparability.After treatment,ALB significantly increased in both groups,while TC,TG,and 24-hour urine protein quantification signif-icantly decreased.Compared with the same group before treatment,the difference was statistically significant(P＜0.05),and the increase/decrease in the treatment group was more significant(P＜0.05).There was no statistically significant difference(P＞0.05)in PLT,FIB,APTT,and D-dimer between the two groups before treatment,indica-ting comparability.After treatment,PLT,FIB,D-dimer significantly decreased and APTT significantly increased in the two groups.Compared with the same group before treatment,the difference was statistically significant(P＜0.05),and the decrease/increase in the treatment group was more significant(P＜0.05).The comparison of CD4+,CD8+,and CD4+/CD8+ratios between the two groups before treatment showed no statistically significant difference(P＞0.05),indicating comparability.After treatment,the CD4+and CD4+/CD8+ratios in the two groups significantly increased,while CD8+significantly decreased.Compared with the same group before treatment,the difference was statistically significant(P＜0.05),and the increase/decrease in the treatment group was more signifi-cant(P＜0.05).The comparison of TCM syndrome scores between the two groups before treatment showed no statis-tically significant difference(P＞0.05),indicating comparability.After treatment,the TCM syndrome scores of the two groups significantly decreased,with a statistically significant difference compared to before treatment in the same group(P＜0.05),and the treatment group showed a more significant decrease(P＜0.05).Conclusion Modified Fangji Huangqi Tang has satisfactory effect in the adjuvant treatment of PNS with lung-spleen qi deficiency syn-drome,which can significantly reduce TCM syndrome score,urinary protein quantity and lipid level,improve coagu-lation function and immune function of children,and is worthy of clinical application.
NETL
NSTL
万方数据
