Clinical observation on 54 cases of pediatric cough variant asthma with phlegm-heat congestion of the lung syndrome treated with the aid of modified Wuhu Tang(五虎汤)
Objective To observe the clinical efficacy of the adjuvant treatment of pediatric cough variant asth-ma with phlegm-heat congestion of the lung syndrome by modified Wuhu Tang(五虎汤).Methods 108 children with cough variant asthma with phlegm-heat congestion of the lungs syndrome attending the paediatrics department of Linping District Maternal and Child Healthcare Hospital of Hangzhou City from January 2020 to January 2021 were selected and divided into the control group and the treatment group,each with 54 cases,using the random number table method.The control group was given fluticasone propionate inhalation aerosol inhalation treatment,and the treatment group was given modified Wuhu Tang treatment on the basis of the treatment of the control group,and the two groups were compared before and after 4 weeks of treatment in terms of the primary symptoms,secondary symptoms,and total points of symptoms in traditional Chinese medicine,lung function indexes,and serum inflamma-tory levels.Results Before treatment,there was no statistically significant difference in the total points of primary symptoms,secondary symptoms and syndromes between the 2 groups(P＞0.05),and the differences were compara-ble;after treatment,the points of each of the 2 groups were significantly reduced compared with those of the same group before treatment,and the differences were statistically significant(P＜0.05),and the reduction in the treat-ment group was more significant(P＜0.05).Comparison of exertion lung volume(FVC),exertion expiratory volume in the first second(FEV1),peak expiratory flow rate(PEF),and FEV1/FVC between the two groups before treat-ment,the differences were not statistically significant(P＞0.05)and were comparable;after treatment,the above in-dexes of the two groups were significantly higher than those of the same group before treatment,and the differences were statistically significant(P＜0.05),with a more significant increase in the treatment group(P＜0.05),and the increase was more significant in the treatment group(P＜0.05).Comparison of serum leukotriene D4(LTD4),nerve growth factor(NGF),interleukin-6(IL-6),tumour necrosis factor alpha(TNF-α)and ultrasensitive C-reactive protein(hs-CRP)between the two groups before treatment was not statistically significant(P＞0.05),and was com-parable;the levels of the above indexes in the two groups were significantly reduced after treatment,and the differ-ences were statistically significant(P＜0.05),and the reduction was more significant in the treatment group(P＜0.05).Conclusion The efficacy of modified Wuhu Tang in treating paediatric CVA with phlegm-heat conges-tion of the lungs is satisfactory,which can not only effectively reduce the TCM symptom score and improve the lung function indexes,but also inhibit the inflammatory response of the airway,which is worthy of clinical promotion and application.
pediatric cough variant asthmaphlegm-heat congestion of the lungsmodified Wuhu Tang(五虎汤)clinical observation
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