Clinical observation on the adjuvant treatment of 90 cases of pediatric asthmatic bronchitis with phlegm heat accumulating in the lung pattern using Pingchuan Zhike Fang(平喘止咳方)
Objective To observe the clinical efficacy of Pingchuan Zhike Fang(平喘止咳方)in the adjuvant treatment of pediatric asthmatic bronchitis with phlegm heat accumulating in the lung pattern.Methods A total of 180 pediatric patients with asthmatic bronchitis and phlegm heat accumulating in the lung pattern who were admit-ted to the pediatric inpatient department of Taizhou Hospital of Zhejiang Province from April 2020 to April 2023 were selected and randomly divided into a control group and a treatment group,with 90 patients in each group.Both groups received symptomatic treatments such as anti-infection,anti-asthmatic,and antitussive therapy.The control group was treated with nebulized inhalation of 1 mL of Terbutaline Sulfate Solution for Inhalation mixed with 2 mL of Budesonide Suspension for Inhalation.The treatment group was further treated with the self-formulated Pingchuan Zhike Fang based on the control group's treatment regimen.Clinical efficacy was evaluated after 7 days of treatment in both groups.Results The total effective rate was 88.89％(80/90)in the control group and 97.78％(88/90)in the treatment group,with a statistically significant difference between the two groups(P＜0.05).Before treatment,there were no statistically significant differences in respiratory rate(RR),tidal volume(VT),inspiratory-to-expira-tory time ratio(Ti/Te),time to peak tidal expiratory flow ratio(TPTEF/TE),and peak expiratory flow volume ratio(VPEF/VE)between the two groups(P＞0.05),indicating comparability.After treatment,both RR and Ti/Te sig-nificantly decreased,while VT,TPTEF/TE,and VPEF/VE significantly increased in both groups,with statistically significant differences compared to pre-treatment values within each group.The decrease or increase was more pro-nounced in the treatment group(P＜0.05).Before treatment,there were no statistically significant differences in eo-sinophil and eosinophil cationic protein levels between the two groups(P＞0.05),indicating comparability.After treatment,both eosinophil and eosinophil cationic protein levels significantly decreased in both groups,with statisti-cally significant differences compared to pre-treatment values within each group.The decrease was more pronounced in the treatment group(P＜0.05).Before treatment,there were no statistically significant differences in serum inter-leukin-5(IL-5),interleukin-25(IL-25),and interleukin-33(IL-33)levels between the two groups(P＞0.05),in-dicating comparability.After treatment,all these indices significantly decreased in both groups,with statistically sig-nificant differences compared to pre-treatment values within each group.The decrease was more pronounced in the treatment group(P＜0.05).Conclusion The adjuvant treatment of pediatric asthmatic bronchitis with phlegm heat accumulating in the lung pattern using Pingchuan Zhike Fang has significant clinical efficacy,can significantly im-prove lung function,regulate inflammatory markers,and serum cytokine levels,and is worthy of clinical promotion and application.
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