平喘止咳方辅助治疗儿童喘息性支气管炎痰热壅肺证90例临床观察
Clinical observation on the adjuvant treatment of 90 cases of pediatric asthmatic bronchitis with phlegm heat accumulating in the lung pattern using Pingchuan Zhike Fang(平喘止咳方)
俞慧君 1孙颖 1郑亚玲2
作者信息
- 1. 浙江省台州医院儿科,浙江 台州 318050
- 2. 浙江省台州医院中医科,浙江 台州 318050
- 折叠
摘要
目的 观察平喘止咳方辅助治疗儿童喘息性支气管炎痰热壅肺证的临床疗效.方法 选取2020年4月至2023年4月浙江省台州医院儿科住院部收治的喘息性支气管炎痰热壅肺证患儿180例,按照随机数字表法分为对照组和治疗组,各90例.2组均给予抗感染、平喘、止咳等对症治疗,对照组予吸入用硫酸特布他溶液1 mL+吸入用布地奈德混悬液2 mL混合后雾化吸入,治疗组在对照组治疗方法的基础上给予自拟平喘止咳方治疗,2组均治疗7 d后统计临床疗效.结果 对照组总有效率为88.89％(80/90),治疗组为97.78％(88/90),2组比较,差异有统计学意义(P＜0.05).治疗前,2组呼吸频率(RR)、潮气量(VT)、吸呼比(Ti/Te)、达峰时间比(TPTEF/TE)与达峰容积比(VPEF/VE)比较,差异无统计学意义(P＞0.05),具有可比性;治疗后,2组RR、Ti/Te显著下降,VT、TPTEF/TE、VPEF/VE显著升高,与同组治疗前比较,差异均有统计学意义(P＜0.05),且治疗组下降或升高更显著(P＜0.05).治疗前,2组嗜酸性粒细胞、嗜酸性粒细胞阳离子蛋白水平比较,差异无统计学意义(P＞0.05),具有可比性;治疗后,2组嗜酸性粒细胞、嗜酸性粒细胞阳离子蛋白水平均显著降低,与同组治疗前比较,差异有统计学意义(P＜0.05),且治疗组降低更显著(P＜0.05).治疗前,2组血清白细胞介素-5(IL-5)、白细胞介素-25(IL-25)及白细胞介素-33(IL-33)水平比较,差异无统计学意义(P＞0.05),具有可比性;治疗后,2组上述指标水平均显著下降,与同组治疗前比较,差异有统计学意义(P＜0.05),且治疗组下降更显著(P＜0.05).结论 平喘止咳方辅助治疗儿童喘息性支气管炎痰热壅肺证临床疗效确切,能显著改善肺功能,调节炎症指标和血清炎症因子水平,值得临床推广应用.
Abstract
Objective To observe the clinical efficacy of Pingchuan Zhike Fang(平喘止咳方)in the adjuvant treatment of pediatric asthmatic bronchitis with phlegm heat accumulating in the lung pattern.Methods A total of 180 pediatric patients with asthmatic bronchitis and phlegm heat accumulating in the lung pattern who were admit-ted to the pediatric inpatient department of Taizhou Hospital of Zhejiang Province from April 2020 to April 2023 were selected and randomly divided into a control group and a treatment group,with 90 patients in each group.Both groups received symptomatic treatments such as anti-infection,anti-asthmatic,and antitussive therapy.The control group was treated with nebulized inhalation of 1 mL of Terbutaline Sulfate Solution for Inhalation mixed with 2 mL of Budesonide Suspension for Inhalation.The treatment group was further treated with the self-formulated Pingchuan Zhike Fang based on the control group's treatment regimen.Clinical efficacy was evaluated after 7 days of treatment in both groups.Results The total effective rate was 88.89％(80/90)in the control group and 97.78％(88/90)in the treatment group,with a statistically significant difference between the two groups(P＜0.05).Before treatment,there were no statistically significant differences in respiratory rate(RR),tidal volume(VT),inspiratory-to-expira-tory time ratio(Ti/Te),time to peak tidal expiratory flow ratio(TPTEF/TE),and peak expiratory flow volume ratio(VPEF/VE)between the two groups(P＞0.05),indicating comparability.After treatment,both RR and Ti/Te sig-nificantly decreased,while VT,TPTEF/TE,and VPEF/VE significantly increased in both groups,with statistically significant differences compared to pre-treatment values within each group.The decrease or increase was more pro-nounced in the treatment group(P＜0.05).Before treatment,there were no statistically significant differences in eo-sinophil and eosinophil cationic protein levels between the two groups(P＞0.05),indicating comparability.After treatment,both eosinophil and eosinophil cationic protein levels significantly decreased in both groups,with statisti-cally significant differences compared to pre-treatment values within each group.The decrease was more pronounced in the treatment group(P＜0.05).Before treatment,there were no statistically significant differences in serum inter-leukin-5(IL-5),interleukin-25(IL-25),and interleukin-33(IL-33)levels between the two groups(P＞0.05),in-dicating comparability.After treatment,all these indices significantly decreased in both groups,with statistically sig-nificant differences compared to pre-treatment values within each group.The decrease was more pronounced in the treatment group(P＜0.05).Conclusion The adjuvant treatment of pediatric asthmatic bronchitis with phlegm heat accumulating in the lung pattern using Pingchuan Zhike Fang has significant clinical efficacy,can significantly im-prove lung function,regulate inflammatory markers,and serum cytokine levels,and is worthy of clinical promotion and application.
关键词
儿童/喘息性支气管炎/痰热壅肺证/平喘止咳方/临床观察Key words
children/asthmatic bronchitis/phlegm-heat obstructing lung syndrome/Pingchuan Zhike Fang(平喘止咳方)/clinical observation引用本文复制引用
基金项目
台州市第一批社会发展科技计划项目(21ywa52)
出版年
2024
国家科技期刊平台
NSTL
万方数据