Objective To observe the clinical efficacy of Xiaoqinglong Tang(小青龙汤)as adjuvant therapy in pediatric allergic rhinitis with lung qi deficiency cold pattern.Methods A total of 118 pediatric patients with al-lergic rhinitis and lung qi deficiency cold pattern admitted to the Ophthalmology and Otorhinolaryngology Depart-ment of Jiangnan Hospital Affiliated to Zhejiang Chinese Medical University from September 2019 to March 2023 were selected and randomly divided into a control group and a treatment group,with 59 patients in each group.Both groups received symptomatic treatment,including nasal irrigation with saline and reducing allergen exposure.The control group was given loratadine syrup orally,while the treatment group received Xiaoqinglong Tang in addition to the control group's treatment.Both groups underwent two-week treatment cycles for a total of two cycles,and the ef-ficacy was evaluated after six months of follow-up.Results The total effective rate was 77.97％(46/59)in the control group and 91.53％(54/59)in the treatment group,with a statistically significant difference between the two groups(P＜0.05).Before treatment,there were no statistically significant differences in the scores of primary symp-toms(nasal congestion,nasal itching,rhinorrhea,sneezing)and secondary symptoms(spontaneous sweating,short-ness of breath,lack of energy,fatigue)between the two groups(P＞0.05),indicating comparability.After treatment,the scores of both primary and secondary symptoms decreased significantly in both groups compared with before treatment(P＜0.05),with more significant reductions in the treatment group(P＜0.05).Before treatment,there were no statistically significant differences in serum eosinophil(EOS),helper T lymphocyte 1(Th1),helper T lym-phocyte 2(Th2),Th1/Th2,specific immunoglobulin E(sIgE),and specific immunoglobulin G4(sIgG4)levels between the two groups(P＞0.05),indicating comparability.After treatment,serum EOS,sIgE,and Th2 levels de-creased significantly,while sIgG4,Th1,and Th1/Th2 levels increased significantly in both groups compared with be-fore treatment(P＜0.05),with more significant changes in the treatment group(P＜0.05).Before treatment,there were no statistically significant differences in interleukin-6(IL-6),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α),and aquaporin 5(AQP5)levels between the two groups(P＞0.05),indicating comparability.After treat-ment,serum IL-6,TNF-α,and AQP5 levels decreased significantly,while IL-10 levels increased significantly in both groups compared with before treatment(P＜0.05),with more significant changes in the treatment group(P＜0.05).Before treatment,there were no statistically significant differences in nasal endoscopy scores and nasal resistance between the two groups(P＞0.05),indicating comparability.After treatment,nasal endoscopy scores and nasal resistance decreased significantly in both groups compared with before treatment(P＜0.05),with more signifi-cant reductions in the treatment group(P＜0.05).In the treatment group,2 cases of nausea and retching occurred,both of which resolved spontaneously after rest and adequate hydration.Conclusion Xiaoqinglong Tang as adjuvant therapy for pediatric allergic rhinitis with lung qi deficiency cold pattern can effectively improve clinical symptoms,regulate immune indicators,reduce inflammatory responses,and has minimal adverse reactions,making it worthy of clinical promotion and application.
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