Exploring the medication patterns of professor XUAN Guiqi in treating childhood attention deficit hyperactivity disorder based on data mining technology
Objective To mine the clinical medication patterns of professor XUAN Guiqi in treating childhood attention deficit hyperactivity disorder(ADHD)based on the Traditional Chinese Medicine Inheritance Calculation Platform(TCMICS V3.0).Methods Clinical case records of ADHD patients treated by professor XUAN from 2018 to 2022 were collected,and standardized data were entered into TCMICS V3.0 for data mining to identify medica-tion patterns.Results A total of 88 ADHD patients treated by professor XUAN were included,revealing 20 high-frequency symptoms.Across 227 clinical cases,115 Chinese medicinal herbs were used,with 32 herbs having a fre-quency of use ≥17 times.The top 10 herbs were Polygala tenuifolia Willd.,Alpinia oxyphylla Miq.,Plastrum testu-dinis,Radix Paeoniae Alba,Apatite,Magnetitum,Acorus tatarinowii Schott,Curcuma aromatica,Poria cum Radix Pini,and Polygonatum kingianum Coll.et Hemsl.These herbs primarily belonged to the categories of tonifying defi-ciency,calming the mind,and astringency.Most herbs were cold in nature,followed by warm and neutral;tastes were predominantly bitter,sweet,and pungent;and the meridian tropisms were primarily associated with the kidney,liver,and heart meridians.In correlation and cluster analysis,high-frequency herbs were often modified based on the formula of Kongsheng Zhenzhong Dan(孔圣枕中丹).Conclusion Professor XUAN believes that the primary path-ogenesis of childhood ADHD is insufficient kidney qi leading to hyperactivity of liver yang and malnutrition of the brain.Deficiency,fire,phlegm,and improper diet are important pathological factors.Treatment primarily focuses on nourishing the kidney,with attention also given to the liver and heart.Emphasis is placed on family education and dietary regulation.The therapeutic approach is primarily aimed at nourishing the kidney and suppressing yang hyper-activity,nourishing yin and opening orifices,supplemented by calming the mind.Additionally,digestion-promoting,phlegm-resolving,heat-clearing,and blood-stasis-removing herbs are used.A combination of cold and warm herbs,as well as static and dynamic principles,is applied flexibly with rigorous compatibility,achieving the goal of balancing yin and yang and achieving satisfactory clinical outcomes.
childhood attention deficit hyperactivity disorderXUAN's pediatricsdata miningTraditional Chinese Medicine Inheritance Calculation Platform V3.0XUAN Guiqi
NETL
NSTL
万方数据
