Clinical observation on 56 cases of female children with idiopathic central precocious puberty(ICPP)of liver qi stagnation transforming into fire pattern treated with modified Xiaoyao San(逍遥散)as adjuvant therapy
Objective To observe the clinical efficacy of modified Xiaoyao San(逍遥散)as adjuvant therapy in female children with idiopathic central precocious puberty(ICPP).Methods A total of 112 female children with ICPP of liver qi stagnation transforming into fire pattern admitted to the pediatric outpatient clinic of Huzhou Traditional Chinese Medicine Hospital from January 2018 to January 2023 were enrolled and randomly divided into a treatment group and a control group,with 56 cases in each group.The control group was treated with intramuscular injection of triptorelin acetate,while the treatment group was treated with modified Xiaoyao San on the basis of the control group's treatment.Both groups were fasting from health supplements during treatment,prohibited from using other similar drugs,maintained adequate sleep,adhered to exercise for at least 1 hour per day.One course of treat-ment lasted for 4 weeks,and the clinical efficacy was evaluated after 3 courses of treatment.Results The total ef-fective rate was 94.64％(53/56)in the treatment group,which was better than 80.36％(45/56)in the control group,with a statistically significant difference between the two groups(P＜0.05).Before treatment,there was no statistically significant difference in the total score of traditional Chinese medicine(TCM)syndromes between the two groups(P＞0.05),indicating comparability.After treatment,the TCM syndrome scores of both groups decreased significantly,with a statistically significant difference compared with before treatment in the same group(P＜0.05),and the decrease was more significant in the treatment group(P＜0.05).Before treatment,there were no statistically significant differences in breast bud diameter,uterine volume,and ovarian volume between the two groups(P＞0.05),indicating comparability.After treatment,these physical signs significantly decreased in both groups,with a statistically significant difference compared with before treatment in the same group(P＜0.05),and the decrease was more significant in the treatment group(P＜0.05).Before treatment,there were no statistically significant differ-ences in serum estradiol(E2),luteinizing hormone(LH),and follicle-stimulating hormone(FSH)levels between the two groups(P＞0.05),indicating comparability.After treatment,these hormone levels significantly decreased in both groups,with a statistically significant difference compared with before treatment in the same group(P＜0.05),and the decrease was more significant in the treatment group(P＜0.05).Conclusion Modified Xiaoyao San as ad-juvant therapy for female children with ICPP of liver qi stagnation transforming into fire pattern can effectively alle-viate clinical symptoms and signs,inhibit the development of secondary sexual characteristics,and regulate serum sex hormone levels,worthy of clinical promotion and application.
female childrenidiopathic central precocious puberty(ICPP)liver qi stagnation transforming into fire patternmodified Xiaoyao San(逍遥散)sex hormonesclinical observation
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