Exploring the therapeutic mechanism of Suanzaoren Tang(酸枣仁汤)in treating pediatric sleep disorders of liver qi stagnation and blood deficiency pattern based on the hypothalamus-pituitary-target gland multi-axis
Objective To explore the clinical efficacy and mechanism of Suanzaoren Tang(酸枣仁汤)in trea-ting pediatric sleep disorders of liver qi stagnation and blood deficiency pattern based on the hypothalamus-pituitary-target gland multi-axis.Methods Thirty children with sleep disorders treated in No.2 Rehabilitation Department of Shenyang Children's Hospital from August 2021 to March 2024 were enrolled,and thirty healthy children matched for age,gender,and other factors with the treatment group were selected as the control group.The control group only received health examinations,while the treatment group received oral administration of Suanzaoren Tang for two con-secutive weeks,and clinical efficacy was assessed after treatment.Results After treatment,the Children's Sleep Habits Questionnaire(CSHQ)scores,as well as the primary and secondary symptom scores,significantly decreased in the treatment group compared with before treatment,with statistically significant differences(P＜0.05).Before treatment,serum adrenocorticotropic hormone(ACTH)levels were significantly increased in the treatment group compared with the control group,with statistically significant differences(P＜0.05);after treatment,ACTH levels significantly decreased,while thyroid-stimulating hormone(TSH)levels significantly increased in the treatment group,with statistically significant differences compared with before treatment within the same group and the control group(P＜0.05).Before treatment,total thyroxine(TT4)levels were significantly decreased,while cortisol(CORT)levels were significantly increased in the treatment group compared with the control group,with statistical-ly significant differences(P＜0.05);after treatment,TT4,total triiodothyronine(TT3),and CORT levels decreased in the treatment group compared with before treatment within the same group,with statistically significant differ-ences(P＜0.05).During the observation period,one case of nausea and vomiting occurred in the treatment group,which disappeared after discontinuation of the medication,with an adverse reaction rate of 3.33％(1/30).Conclu-sion Suanzaoren Tang for treating pediatric sleep disorders of liver qi stagnation and blood deficiency pattern can significantly improve clinical symptoms,regulate hypothalamus-pituitary-target gland multi-axis function,and is highly safe and suitable for clinical application and promotion.
hypothalamus-pituitary-target gland multi-axispediatric sleep disordersliver qi stagnation and blood deficiency patterSuanzaoren Tang(酸枣仁汤)clinical observationmechanism of action
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