Clinical observation on 42 cases of pediatric asthma with allergic rhinitis of lung and spleen qi deficiency pattern treated with Peiyuan Shengjin Tongqiao Tang(培元生金通窍汤)
Objective To observe the clinical efficacy of Peiyuan Shengjin Tongqiao Decoction(培 元生金通窍汤)in the treatment of pediatric asthma with allergic rhinitis of lung and spleen qi deficiency pattern.Methods A total of 86 pediatric patients with asthma and allergic rhinitis admitted to the TCM Department of Hangzhou No.9 People's Hospital between January 2022 and June 2023 were enrolled and randomly divided into a treatment group and a control group using a random number table.The control group received conventional Western medicine treat-ment,while the treatment group received Peiyuan Shengjin Tongqiao Tang in addition to the control group's treat-ment.The clinical efficacy,traditional Chinese medicine(TCM)symptom scores before and after treatment,serum levels of surfactant protein-A(SP-A)and surfactant protein-D(SP-D),and serum levels of inflammatory cytokines interleukin(IL)-6,IL-17,IL-10,and IL-35 were recorded and analyzed.Results The total effective rate in the treatment group was 95.24％(40/42),significantly higher than that in the control group 79.55％(35/44);the difference between the two groups was statistically significant(P＜0.05).Before treatment,there were no statistical-ly significant differences in TCM symptom scores for wheezing,cough,nasal obstruction,nasal itching,sneezing,and sweating between the two groups(P＞0.05),indicating comparability.After treatment,the TCM symptom scores for all the above symptoms decreased in both groups compared with those before treatment,with statistically signifi-cant differences(P＜0.05);the decrease was more significant in the treatment group(P＜0.05).Before treatment,there were no statistically significant differences in serum levels of SP-A and SP-D between the two groups(P＞0.05),indicating comparability.After treatment,the levels of these indicators decreased in both groups com-pared with those before treatment,with statistically significant differences(P＜0.05);the decrease was more signifi-cant in the treatment group(P＜0.05).Before treatment,there were no statistically significant differences in serum levels of IL-6,IL-17,IL-10,and IL-35 between the two groups(P＞0.05),indicating comparability.After treatment,the levels of IL-6 and IL-17 decreased,while the levels of IL-10 and IL-35 increased in both groups compared with those before treatment,with statistically significant differences(P＜0.05);the decrease or increase was more signifi-cant in the treatment group(P＜0.05).Conclusion Peiyuan Shengjin Tongqiao Tang demonstrates satisfactory therapeutic efficacy in the treatment of pediatric patients with asthma and allergic rhinitis.It not only significantly improves the clinical symptoms of the patients but also regulates and reduces serum levels of inflammatory cytokines and SP-A,SP-D.Thus,it is worthy of clinical promotion and application.
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