Efficacy of the Qingjin Huatan decoction on intestinal flora in patients with chronic obstructive pulmonary disease of the phlegm-heat obstructing lung type
Objective:To observe the changes of intestinal flora in patients with chronic obstructive pulmonary disease(COPD)of the phlegm-heat obstructing lung type,and to explore the possible mechanism of the Qingjin Huatan decoction(清金化痰汤)in treating COPD of the phlegm-heat obstructing lung type.Methods:From January 2021 to October 2022,a total of 50 patients(with 47 males and 3 females)with COPD of the phlegm-heat obstructing lung type,aged(72.78±8.98)years,they were collected from the respiratory and critical care medical ward of the Third People's Hospital affiliated to Fujian University of Traditional Chinese Medicine.On the basis of conventional Western medicine treatment,the Qingjin Huatan decoction was used for 7 days.16S rRNA sequencing was used to analyze the intestinal flora of the patients before and after treatment.Results:①A total of 1 414 OTU data were detected in the stool samples of 100 patients in this study,including 921 OTU data in two groups,and 264 and 229 OTU data in each group before and after treatment.②At the level of phylum,the intestinal microflora of patients before treatment were mainly patescibacteria,firmicutes,and bacteroidetes.After treatment,the intestinal flora of patients is mainly actinobacteria,cyanobacteria and epsilonbacteraeota.③Taking genus level classification as an example,the abundance of the intestinal flora of patients after treatment includes akkermansia,escherichia-shigella,ruminococcus_2,un_f_clostridiales_vadinbb60_group,un_f_lachnospiraceae trichospiridae in the group was higher than that before treatment.After treatment,the abundance of anaerosporobacter,megasphaera,parabacteroides,prevotella_7,pyramidobacter were lower than before treatment.Conclusion:The Qingjin Huatan decoction may inhibit inflammatory reaction and improve the condition of patients with copd by increasing the level of beneficial bacteria in the intestines of patients with the phlegm-heat obstructing lung.
万方数据
维普
