A Meta-analysis of efficacy and safety of the Shensong Yangxin capsules on tachyarrhythmia
Objective:To systematically evaluate the efficacy and safety of the Shensong Yangxin capsules(参松养心胶囊)on tachyarrhythmia.Methods:The RCTs of the Shensong Yangxin capsules on tachyarrhythmias were retrieved from PubMed,Web of Science,the Cochrane library,Embase,CBM,CNKI,Wanfang,VIP,and the time limit was to build the database until September 2022.Two researchers independently screened the literature,extracted data and evaluated the quality of the included studies according to the Cochrane handbook.Data analysis by RevMan 5.3 software.Funnel plots were drawn to evaluate the publication bias of the included studies.Results:A total of 42 RCTs involving 3 867 patients were included,patients of the Shensong Yangxin capsules combined with conventional western medicine treatment are 1 952,patients of conventional western medicine treatment are 1 915.The results of Meta-analysis showed that compared with conventional western medicine treatment,the Shensong Yangxin capsules combined with conventional western medicine were effective on clinical total effective(RR=1.18,95%CI=[1.13,1.22],P<0.000 01),heart rate(HR)(MD=-8.29,95%CI=[-12.29,-4.29],P<0.000 1),left ventricular ejection fraction(LVEF)(MD=4.90,95%CI=[3.48,6.33],P<0.000 01),left ventricular end-diastolic diameter(LVEDD)(MD=-6.94,95%CI=[-8.50,-5.38],P<0.000 01),left ventricular end-systolic diameter(LVESD)(MD=-4.62,95%CI=[-4.93,-4.31],P<0.000 01),6-minute walk test(6MWT)(MD=72.36,95%CI=[27.39,117.34],P=0.002)and adverse reaction(RR=0.65,95%CI=[0.49,0.86],P=0.002).Conclusion:The current evidence shows that the Shensong Yangxin capsules combined with conventional western medicine in the treatment of tachyarrhythmia have significant curative effects on the total clinical effective rate,HR,LVEF,LVEDD,LVESD,6MWT,and the incidence of adverse reactions is low.However,due to the limitations of the quality and quantity of included studies.In the future,it is still necessary to carry out large-sample,multi-center,randomized,double-blind,placebo-controlled trials that can reflect the principles of TCM diagnosis and treatment to further verify the conclusions.
The Shensong Yangxin capsulesTachyarrhythmiaRandomized controlled trialsMeta-analysis
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