A Meta-analysis of the efficacy of the Zhenwu decoction plus Guizhi Fuling Wan plus conventional drugs on chronic heart failure
Objective:To evaluate the efficacy of the Zhenwu decoction(真武汤)and Guizhi Fuling Wan(桂枝茯苓丸)combined with conventional drugs on chronic heart failure.Methods:The databases of CNKI,Wanfang Data,VIP,CBM,PubMed,Cochrane Library,Web of Science,Embase were searched systematically,to collect the clinical RCTs of the Zhenwu decoction and Guizhi Fuling Wan on chronic heart failure.Related articles from the database inception to November 6,2022 were searched.A Meta-analysis was carried out by RevMan 5.3 software after two independent researchers screened the literature,extracted the data and evaluated the risk of bias.Results:The total sample size of 7 included RCTs were 684 cases,including 344 cases in the experimental group and 340 cases in the control group.A Meta analysis showed that the clinical comprehensive effect in the experimental group was significantly higher than that in the control group after treatment,and the difference was statistically significant[OR=4.77,95%CI(2.97,7.67),P<0.000 01].he level of serum BNP was decreased[MD=-70.90,95%CI(-122.89,-18.92),P= 0.008].The serum NT-proBNP was decreased[MD=-0.66,95%CI(-1.27,-0.05),P<0.03].LVEF was elevated[MD=4.64,95%CI(3.19,6.09),P<0.000 01].LVEDD was decreased[MD=-3.49,95%CI(-4.10,-2.88),P<0.000 01].TNF-α was reduced[MD=-4.05,95%CI(-6.18,-1.91),P=0.000 2].The hs-CRP was reduced[MD=-2.23,95%CI(-2.99,-1.47),P<0.000 01].Conclusion:The present evidence shows that the Zhenwu decoction plus Guizhi Fuling Wan combined with conventional medicine has a better therapeutic effect on chronic heart failure,which can improve cardiac function and prognosis,and the effect is better than that of western medicine alone.Due to the limitation of the quantity and quality of the included studies,the above conclusions need to be verified by more high-quality studies.
The Zhenwu decoction and Guizhi Fuling WanChronic heart failureSystematic reviewMeta-analysisRandomized controlled trial
万方数据
维普
